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Literature DB >> 23038402

An RNA-deaminase conjugate selectively repairs point mutations.

Thorsten Stafforst¹, Marius F Schneider.

Abstract

Checking for mistakes: By conjugating a catalytic domain with a guide RNA, deamination activity can be harnessed to repair a specific codon on mRNA. This method can be used for the highly selective repair of point mutations in mRNA by site-selective editing.

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Year: 2012 PMID： 23038402 DOI： 10.1002/anie.201206489

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

41 in total

1. Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells.

Authors: Brodie L Ranzau; Alexis C Komor
Journal: Biochemistry Date: 2018-12-12 Impact factor: 3.162

Review 2. Current strategies for Site-Directed RNA Editing using ADARs.

Authors: Maria Fernanda Montiel-Gonzalez; Juan Felipe Diaz Quiroz; Joshua J C Rosenthal
Journal: Methods Date: 2018-11-29 Impact factor: 3.608

3. Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing.

Authors: Maria Fernanda Montiel-Gonzalez; Isabel Vallecillo-Viejo; Guillermo A Yudowski; Joshua J C Rosenthal
Journal: Proc Natl Acad Sci U S A Date: 2013-10-09 Impact factor: 11.205

4. REPAIRx, a specific yet highly efficient programmable A > I RNA base editor.

Authors: Yajing Liu; Shaoshuai Mao; Shisheng Huang; Yongqin Li; Yuxin Chen; Minghui Di; Xinxin Huang; Junjun Lv; Xinxin Wang; Jianyang Ge; Shengxi Shen; Xiaoming Zhang; Dahai Liu; Xingxu Huang; Tian Chi
Journal: EMBO J Date: 2020-10-15 Impact factor: 11.598

Review 5. A-to-I RNA editing - immune protector and transcriptome diversifier.

Authors: Eli Eisenberg; Erez Y Levanon
Journal: Nat Rev Genet Date: 2018-08 Impact factor: 53.242

6. Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme.

Authors: Isabel C Vallecillo-Viejo; Noa Liscovitch-Brauer; Maria Fernanda Montiel-Gonzalez; Eli Eisenberg; Joshua J C Rosenthal
Journal: RNA Biol Date: 2017-11-13 Impact factor: 4.652

An RNA-deaminase conjugate selectively repairs point mutations.

1. Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells.

Review 2. Current strategies for Site-Directed RNA Editing using ADARs.

3. Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing.

4. REPAIRx, a specific yet highly efficient programmable A > I RNA base editor.

Review 5. A-to-I RNA editing - immune protector and transcriptome diversifier.

6. Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme.

Review 7. Off-Target Editing by CRISPR-Guided DNA Base Editors.

Review 8. Editing the Genome Without Double-Stranded DNA Breaks.

9. RNA editing with CRISPR-Cas13.

Review 10. Base editing: precision chemistry on the genome and transcriptome of living cells.