Literature DB >> 23034674

Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli.

Yanxiang Shi1, Alejandro Bueno, Wilfred A van der Donk.   

Abstract

We report the heterologous production of Ala(0)actagardine in E. coli by co-expression of the substrate peptide GarA and its modification enzymes GarM and GarO. The activity of GarO, a luciferase-like monooxygenase that introduces the unique sulfoxide group of actagardine, was also investigated in vitro.

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Year:  2012        PMID： 23034674      PMCID： PMC3485686          DOI： 10.1039/c2cc36336d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  22 in total

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Authors:  Patrick J Knerr; Wilfred A van der Donk
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Review 2.  Bacterial lantibiotics: strategies to improve therapeutic potential.

Authors:  Paul D Cotter; Colin Hill; R Paul Ross
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Review 3.  Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts.

Authors:  W J H van Berkel; N M Kamerbeek; M W Fraaije
Journal:  J Biotechnol       Date:  2006-05-19       Impact factor: 3.307

4.  Ala(0)-actagardine, a new lantibiotic from cultures of Actinoplanes liguriae ATCC 31048.

Authors:  L Vértesy; W Aretz; A Bonnefoy; E Ehlers; M Kurz; A Markus; M Schiell; M Vogel; J Wink; H Kogler
Journal:  J Antibiot (Tokyo)       Date:  1999-08       Impact factor: 2.649

Review 5.  Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism.

Authors:  Sharon K Krueger; David E Williams
Journal:  Pharmacol Ther       Date:  2005-06       Impact factor: 12.310

6.  Gardimycin, a new antibiotic inhibiting peptidoglycan synthesis.

Authors:  S Somma; W Merati; F Parenti
Journal:  Antimicrob Agents Chemother       Date:  1977-03       Impact factor: 5.191

7.  Physico-chemical and biological properties of actagardine and some acid hydrolysis products.

Authors:  A Malabarba; M Landi; R Pallanza; B Cavalleri
Journal:  J Antibiot (Tokyo)       Date:  1985-11       Impact factor: 2.649

8.  The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II.

Authors:  H Brötz; G Bierbaum; K Leopold; P E Reynolds; H G Sahl
Journal:  Antimicrob Agents Chemother       Date:  1998-01       Impact factor: 5.191

9.  The tetracyclic lantibiotic actagardine. 1H-NMR and 13C-NMR assignments and revised primary structure.

Authors:  N Zimmermann; J W Metzger; G Jung
Journal:  Eur J Biochem       Date:  1995-03-15

10.  Oxidative decarboxylation of peptides catalyzed by flavoprotein EpiD. Determination of substrate specificity using peptide libraries and neutral loss mass spectrometry.

Authors:  T Kupke; C Kempter; G Jung; F Götz
Journal:  J Biol Chem       Date:  1995-05-12       Impact factor: 5.157
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  21 in total

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2.  Carboxyl Analogue of Mutacin 1140, a Scaffold for Lead Antibacterial Discovery.

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3.  Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae.

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4.  Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered Using Bioactivity-Coupled HiTES.

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5.  Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis.

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7.  Pseudomycoicidin, a Class II Lantibiotic from Bacillus pseudomycoides.

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8.  Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium.

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Journal:  Cell Chem Biol       Date:  2016-01-28       Impact factor: 8.116

9.  Isolation and structure determination of a new lantibiotic cinnamycin B from Actinomadura atramentaria based on genome mining.

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10.  Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis.

Authors:  Xiao Yang; Wilfred A van der Donk
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