Literature DB >> 27255974

Isolation and structure determination of a new lantibiotic cinnamycin B from Actinomadura atramentaria based on genome mining.

Shinya Kodani1,2,3, Hisayuki Komaki4, Sho Ishimura5, Hikaru Hemmi6, Mayumi Ohnishi-Kameyama6.   

Abstract

New lantibiotic cinnamycin B was isolated from the extract of Actinomadura atramentaria NBRC 14695(T), based on genome mining and chemical investigation. The partial structure of cinnamycin B was established by 2D NMR experiments, which indicated that cinnamycin B had same methyl lanthionine bridging pattern with cinnamycin. The reduction with NaBH4-NiCl2 afforded the reduced cinnamycin B, and MS/MS experiment indicated the presence of hydroxy asparatic acid in the molecule. Cinnamycin B showed an antibacterial activity against Streptomyces antibioticus with dosage of 5 μg (0.5μL, 10 mg/mL solution) at spot-on-lawn testing method. The gene cluster of cinnamycin B on the genome of A. atramentaria was identified and discussed in comparison with that of cinnamycin.

Entities:  

Keywords:  Actinomadura atramentaria NBRC 14695; Genome mining; Lantibiotic; MS/MS analysis; NMR spectrum

Mesh：

Substances：

Year:  2016        PMID： 27255974     DOI： 10.1007/s10295-016-1788-9

Source DB:  PubMed          Journal:  J Ind Microbiol Biotechnol        ISSN： 1367-5435            Impact factor:   3.346


  31 in total

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