Literature DB >> 22973143

Pheochromocytoma: an uncommon presentation of an asymptomatic and biochemically silent adrenal incidentaloma.

Sunil Kumar Kota1, Siva Krishna Kota, Sandip Panda, Kirtikumar D Modi.   

Abstract

Pheochromocytomas are rare tumours originating from the chromaffin tissue. The clinical manifestations are variable and are not specific; as a result, pheochromocytomas often imitate other diseases. The diagnosis is usually established by biochemical studies, i.e., the measurement of catecholamines or their metabolites in urine or plasma, followed by radiographic and scintigraphic studies for localisation. Surgical removal of the tumour is the preferred treatment. We report a 30-year-old woman presenting with an adrenal incidentaloma that was 7.6 × 5.3 × 4.8 cm in size on an abdominal computed tomography scan. Investigations for adrenal hormones, including a low-dose dexamethasone suppression test, plasma aldosterone level, 24-hour urinary metanephrine and vanillylmandelic acid levels, and plasma metanephrine level were all within the normal ranges. During the surgical resection, the patient had a hypertensive spell. Surgery was postponed, and the blood pressure was adequately controlled with α blockers, followed by β blockers. After 2 weeks, the surgery was followed by a pathological biopsy that confirmed the pheochromocytoma diagnosis.

Entities:  

Keywords:  adrenal incidentaloma; catecholamines; hypertension; pheochromocytoma; scintigraphy

Year:  2012        PMID: 22973143      PMCID: PMC3431738     

Source DB:  PubMed          Journal:  Malays J Med Sci        ISSN: 1394-195X


  18 in total

1.  Clinical experience over 48 years with pheochromocytoma.

Authors:  R E Goldstein; J A O'Neill; G W Holcomb; W M Morgan; W W Neblett; J A Oates; N Brown; J Nadeau; B Smith; D L Page; N N Abumrad; H W Scott
Journal:  Ann Surg       Date:  1999-06       Impact factor: 12.969

Review 2.  Clinical review 164: The laboratory diagnosis of adrenal pheochromocytoma: the Mayo Clinic experience.

Authors:  Yogish C Kudva; Anna M Sawka; William F Young
Journal:  J Clin Endocrinol Metab       Date:  2003-10       Impact factor: 5.958

3.  Biochemical diagnosis of pheochromocytoma: which test is best?

Authors:  Jacques W M Lenders; Karel Pacak; McClellan M Walther; W Marston Linehan; Massimo Mannelli; Peter Friberg; Harry R Keiser; David S Goldstein; Graeme Eisenhofer
Journal:  JAMA       Date:  2002-03-20       Impact factor: 56.272

4.  Paragangliomas: assessment of prognosis by histologic, immunohistochemical, and ultrastructural techniques.

Authors:  K E Kliewer; D R Wen; P A Cancilla; A J Cochran
Journal:  Hum Pathol       Date:  1989-01       Impact factor: 3.466

5.  Incidentally discovered adrenal masses: evaluation with gadolinium enhancement and fat-suppressed MR imaging at 0.5 T.

Authors:  P Boraschi; G Braccini; L Grassi; A Campatelli; A Di Vito; F Mosca; G Perri
Journal:  Eur J Radiol       Date:  1997-05       Impact factor: 3.528

Review 6.  Genetic testing for pheochromocytoma.

Authors:  David Karasek; Zdenek Frysak; Karel Pacak
Journal:  Curr Hypertens Rep       Date:  2010-12       Impact factor: 5.369

7.  Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis.

Authors:  K Salmenkivi; J Arola; R Voutilainen; V Ilvesmäki; C Haglund; A I Kahri; P Heikkilä; J Liu
Journal:  J Clin Endocrinol Metab       Date:  2001-05       Impact factor: 5.958

8.  Biopsy of pheochromocytomas and paragangliomas: potential for disaster.

Authors:  Kimberly A Vanderveen; Scott M Thompson; Matthew R Callstrom; William F Young; Clive S Grant; David R Farley; Melanie L Richards; Geoffrey B Thompson
Journal:  Surgery       Date:  2009-12       Impact factor: 3.982

9.  Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene.

Authors:  Henri J L M Timmers; Karel Pacak; Thanh T Huynh; Mones Abu-Asab; Maria Tsokos; Maria J Merino; Bora E Baysal; Karen T Adams; Graeme Eisenhofer
Journal:  J Clin Endocrinol Metab       Date:  2008-10-07       Impact factor: 5.958

10.  Plasma chromogranin A or urine fractionated metanephrines follow-up testing improves the diagnostic accuracy of plasma fractionated metanephrines for pheochromocytoma.

Authors:  Alicia Algeciras-Schimnich; Carol M Preissner; William F Young; Ravinder J Singh; Stefan K G Grebe
Journal:  J Clin Endocrinol Metab       Date:  2007-10-16       Impact factor: 5.958

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  11 in total

Review 1.  PRECISION MEDICINE: AN UPDATE ON GENOTYPE/BIOCHEMICAL PHENOTYPE RELATIONSHIPS IN PHEOCHROMOCYTOMA/PARAGANGLIOMA PATIENTS.

Authors:  Garima Gupta; Karel Pacak
Journal:  Endocr Pract       Date:  2017-03-23       Impact factor: 3.443

2.  Anesthetic Management of Clinically Silent Familial Pheochromocytoma with MEN 2A: A Report of Four Cases.

Authors:  Shipra Aggarwal; Vandana Talwar; Pooja Virmani; Suniti Kale
Journal:  Indian J Surg       Date:  2016-08-15       Impact factor: 0.656

3.  Pre- and peri-operative characteristics, complications and outcomes of patients with biochemically silent pheochromocytomas; a case series.

Authors:  Athanasios Fountas; Georgia Kanti; Spyridoula Glycofridi; Maria A Christou; Athanasia Kalantzi; Irene Giagourta; Athina Markou; Georgia Ntali; Chrysanthi Aggeli; Eleftheria Saoulidou; Antonia Dimakopoulou; George N Zografos; Theodora Kounadi; Stelios Tigas; Labrini Papanastasiou
Journal:  Endocrine       Date:  2022-09-08       Impact factor: 3.925

4.  Characteristic CT features of pheochromocytomas - probability model calculation tool based on a multicentric study.

Authors:  Filip Ctvrtlik; Zbynek Tudos; Paulina Szasz; Zuzana Sedlackova; Igor Hartmann; Jan Schovanek; Zdenek Frysak; Iva Macova; Tomas Zelinka; Milan Hora; Eva Kocova; Jaroslav Pacovsky; Michal Krsek; Viera Lehotska; Emilia Mojtova; Josef Molnar; Vladimir Vanek; Karel Pacak; Jan Baxa
Journal:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub       Date:  2019-09-23       Impact factor: 1.245

5.  Tetralogy of Fallot and pheochromocytoma in a situs inversus totalis: An unusual association.

Authors:  Rubén Kevin Arnold Tapia-Orihuela; Jorge Huaringa-Marcelo; David Loja-Oropeza
Journal:  J Cardiovasc Thorac Res       Date:  2016-09-30

6.  False Positive Radioiodinated Metaiodobenzylguanidine ((123)I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor.

Authors:  Hee Soo Jung; Seok Jun Moon; Yun Mi Kim; Hye Rim Kang; Seok Mo Lee; Soo Jin Jung; Seok Jin Choi; Tae Kyoon Kim; Min Jeong Kwon; Jeong Hyun Park; Soon Hee Lee
Journal:  Case Rep Oncol Med       Date:  2015-03-30

7.  Patients with pheochromocytoma exhibit low aldosterone renin ratio-preliminary reports.

Authors:  Tomoko Yamada; Hidenori Fukuoka; Yusei Hosokawa; Yukiko Odake; Kenichi Yoshida; Ryusaku Matsumoto; Hironori Bando; Yuko Okada; Yushi Hirota; Genzo Iguchi; Wataru Ogawa; Yutaka Takahashi
Journal:  BMC Endocr Disord       Date:  2020-09-11       Impact factor: 2.763

Review 8.  Laparoscopic resection of a large clinically silent paraganglioma at the organ of Zuckerkandl: a rare case report and review of the literature.

Authors:  Xiang Ren; Jiwen Shang; Ruimin Ren; Huajun Zhang; Xue Yao
Journal:  BMC Urol       Date:  2020-10-07       Impact factor: 2.264

Review 9.  Preoperative Management of Pheochromocytoma and Paraganglioma.

Authors:  Fang Fang; Li Ding; Qing He; Ming Liu
Journal:  Front Endocrinol (Lausanne)       Date:  2020-09-29       Impact factor: 5.555

Review 10.  Personalized Management of Pheochromocytoma and Paraganglioma.

Authors:  Svenja Nölting; Nicole Bechmann; David Taieb; Felix Beuschlein; Martin Fassnacht; Matthias Kroiss; Graeme Eisenhofer; Ashley Grossman; Karel Pacak
Journal:  Endocr Rev       Date:  2022-03-09       Impact factor: 19.871

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