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Literature DB >> 22970829

Biocompatible hydrogels by oxime Click chemistry.

Gregory N Grover¹, Jonathan Lam, Thi H Nguyen, Tatiana Segura, Heather D Maynard.

Abstract

Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2012 PMID： 22970829 PMCID： PMC3474544 DOI： 10.1021/bm301346e

Source DB: PubMed Journal: Biomacromolecules ISSN： 1525-7797 Impact factor: 6.988

25 in total

Review 1. Mesenchymal stem cells: biology and potential clinical uses.

Authors: R J Deans; A B Moseley
Journal: Exp Hematol Date: 2000-08 Impact factor: 3.084

Review 2. Hydrogels for tissue engineering: scaffold design variables and applications.

Authors: Jeanie L Drury; David J Mooney
Journal: Biomaterials Date: 2003-11 Impact factor: 12.479

Review 3. Injectable matrices and scaffolds for drug delivery in tissue engineering.

Authors: James D Kretlow; Leda Klouda; Antonios G Mikos
Journal: Adv Drug Deliv Rev Date: 2007-04-06 Impact factor: 15.470

4. Hydrolytic stability of hydrazones and oximes.

Authors: Jeet Kalia; Ronald T Raines
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

Review 5. Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking.

Authors: Isabelle Migneault; Catherine Dartiguenave; Michel J Bertrand; Karen C Waldron
Journal: Biotechniques Date: 2004-11 Impact factor: 1.993

Review 6. Human mesenchymal stem cells and their use in cell-based therapies.

Authors: Helena Motaln; Cristian Schichor; Tamara T Lah
Journal: Cancer Date: 2010-06-01 Impact factor: 6.860

7. Injectable Biodegradable Poly(ethylene glycol)/RGD Peptide Hybrid Hydrogels for in vitro Chondrogenesis of Human Mesenchymal Stem Cells.

Authors: Shao Qiong Liu; Quan Tian; Lei Wang; James L Hedrick; James Hoi Po Hui; Yi Yan Yang; Pui Lai Rachel Ee
Journal: Macromol Rapid Commun Date: 2010-05-25 Impact factor: 5.734

Review 8. Regenerative biomaterials that "click": simple, aqueous-based protocols for hydrogel synthesis, surface immobilization, and 3D patterning.

Authors: Chelsea M Nimmo; Molly S Shoichet
Journal: Bioconjug Chem Date: 2011-10-26 Impact factor: 4.774

9. Positioning multiple proteins at the nanoscale with electron beam cross-linked functional polymers.

Authors: Karen L Christman; Eric Schopf; Rebecca M Broyer; Ronald C Li; Yong Chen; Heather D Maynard
Journal: J Am Chem Soc Date: 2009-01-21 Impact factor: 15.419

10. Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions.

Authors: Cole A DeForest; Kristi S Anseth
Journal: Nat Chem Date: 2011-10-23 Impact factor: 24.427

34 in total

Biocompatible hydrogels by oxime Click chemistry.

Review 1. Mesenchymal stem cells: biology and potential clinical uses.

Review 2. Hydrogels for tissue engineering: scaffold design variables and applications.

Review 3. Injectable matrices and scaffolds for drug delivery in tissue engineering.

4. Hydrolytic stability of hydrazones and oximes.

Review 5. Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking.

Review 6. Human mesenchymal stem cells and their use in cell-based therapies.

7. Injectable Biodegradable Poly(ethylene glycol)/RGD Peptide Hybrid Hydrogels for in vitro Chondrogenesis of Human Mesenchymal Stem Cells.

Review 8. Regenerative biomaterials that "click": simple, aqueous-based protocols for hydrogel synthesis, surface immobilization, and 3D patterning.

9. Positioning multiple proteins at the nanoscale with electron beam cross-linked functional polymers.

10. Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions.

1. Visible light cured thiol-vinyl hydrogels with tunable degradation for 3D cell culture.

2. Biomaterials for 4D stem cell culture.

Review 3. Achieving Controlled Biomolecule-Biomaterial Conjugation.

4. Imine Hydrogels with Tunable Degradability for Tissue Engineering.

Review 5. Designing degradable hydrogels for orthogonal control of cell microenvironments.

6. Keto-Functionalized Polymer Scaffolds As Versatile Precursors to Polymer Side Chain Conjugates.

7. Peptide-functionalized oxime hydrogels with tunable mechanical properties and gelation behavior.

8. Binding of Anticell Adhesive Oxime-Crosslinked PEG Hydrogels to Cardiac Tissues.

9. Oxime cross-linked injectable hydrogels for catheter delivery.

10. Control of Mesh Size and Modulus by Kinetically Dependent Cross-Linking in Hydrogels.