Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase.

Literature DB >> 22967068

New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase.

Zhiguo Yu¹, Sanja Vodanovic-Jankovic, Michael Kron, Ben Shen.

Abstract

Lymphatic filariasis is caused by the Brugia malayi parasite. Three new congeners of the depsipeptide WS9326A (1), WS9326C (2), WS9326D (3), and WS9326E (4), were isolated from Streptomyces sp. 9078 by using a B. malayi asparaginyl-tRNA synthetase (BmAsnRS) inhibition assay. WS9326D specifically inhibits the BmAsnRS, kills the adult B. malayi parasite, and does not exhibit significant general cytotoxicity to human hepatic cells, representing a new lead scaffold for antifilarial drug discovery.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22967068 PMCID： PMC3460372 DOI： 10.1021/ol302298k

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

16 in total

Review 1. Mass drug treatment for lymphatic filariasis and onchocerciasis.

Authors: David H Molyneux; Mark Bradley; Achim Hoerauf; Dominique Kyelem; Mark J Taylor
Journal: Trends Parasitol Date: 2003-11

Review 2. Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Authors: David J Newman; Gordon M Cragg
Journal: J Nat Prod Date: 2012-02-08 Impact factor: 4.050

3. Anthelmintic discovery and development in the animal health industry.

Authors: Debra J Woods; Christelle Lauret; Timothy Geary
Journal: Expert Opin Drug Discov Date: 2007-10 Impact factor: 6.098

4. Capacity building in anthelmintic drug discovery.

Authors: Michael Kron; Fouad Yousif; Bernadette Ramirez
Journal: Expert Opin Drug Discov Date: 2007-10 Impact factor: 6.098

5. Helminth drug initiative.

Authors: Robert G Ridley; Kiyoshi Kita
Journal: Expert Opin Drug Discov Date: 2007-10 Impact factor: 6.098

6. Ivermectin resistance and overview of the Consortium for Anthelmintic Resistance SNPs.

Authors: Roger K Prichard
Journal: Expert Opin Drug Discov Date: 2007-10 Impact factor: 6.098

7. Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase.

Authors: Zhiguo Yu; Sanja Vodanovic-Jankovic; Nathan Ledeboer; Sheng-Xiong Huang; Scott R Rajski; Michael Kron; Ben Shen
Journal: Org Lett Date: 2011-03-15 Impact factor: 6.005

8. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.

Authors: Ethan A Merritt; Tracy L Arakaki; J Robert Gillespie; Eric T Larson; Angela Kelley; Natascha Mueller; Alberto J Napuli; Jessica Kim; Li Zhang; Christophe L M J Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C van Voorhis; Wim G J Hol
Journal: J Mol Biol Date: 2010-02-02 Impact factor: 5.469

9. WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. II. Biological and pharmacological properties of WS9326A and tetrahydro-WS9326A (FK224)

Authors: M Hashimoto; K Hayashi; M Murai; T Fujii; M Nishikawa; S Kiyoto; M Okuhara; M Kohsaka; H Imanaka
Journal: J Antibiot (Tokyo) Date: 1992-07 Impact factor: 2.649

10. An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase.

Authors: M Kron; K Marquard; M Härtlein; S Price; R Leberman
Journal: FEBS Lett Date: 1995-10-23 Impact factor: 4.124

14 in total

1. Application of 3D NMR for Structure Determination of Peptide Natural Products.

Authors: Fan Zhang; Navid Adnani; Emmanuel Vazquez-Rivera; Doug R Braun; Marco Tonelli; David R Andes; Tim S Bugni
Journal: J Org Chem Date: 2015-08-21 Impact factor: 4.354

2. Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites.

Authors: Mostafa E Rateb; Dong Yang; Sanja Vodanovic-Jankovic; Zhiguo Yu; Michael A Kron; Ben Shen
Journal: J Antibiot (Tokyo) Date: 2015-03-04 Impact factor: 2.649

3. New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883.

Authors: Zhikai Guo; Guohui Pan; Zhengren Xu; Dong Yang; Xiangcheng Zhu; Yong Huang; Li-Xing Zhao; Yi Jiang; Yanwen Duan; Ben Shen
Journal: J Antibiot (Tokyo) Date: 2016-10-12 Impact factor: 2.649

Review 4. Leveraging a large microbial strain collection for natural product discovery.

Authors: Andrew D Steele; Christiana N Teijaro; Dong Yang; Ben Shen
Journal: J Biol Chem Date: 2019-09-30 Impact factor: 5.157

5. Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase.

Authors: Shan Wang; William D G Brittain; Qian Zhang; Zhou Lu; Ming Him Tong; Kewen Wu; Kwaku Kyeremeh; Matthew Jenner; Yi Yu; Steven L Cobb; Hai Deng
Journal: Nat Commun Date: 2022-01-10 Impact factor: 17.694

6. Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.

Authors: Pengfei Xie; Ming Ma; Mostafa E Rateb; Khaled A Shaaban; Zhiguo Yu; Sheng-Xiong Huang; Li-Xing Zhao; Xiangcheng Zhu; Yijun Yan; Ryan M Peterson; Jeremy R Lohman; Dong Yang; Min Yin; Jeffrey D Rudolf; Yi Jiang; Yanwen Duan; Ben Shen
Journal: J Nat Prod Date: 2014-01-31 Impact factor: 4.050

7. Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J.

Authors: Mostafa E Rateb; Zhiguo Yu; Yijun Yan; Dong Yang; Tingting Huang; Sanja Vodanovic-Jankovic; Michael A Kron; Ben Shen
Journal: J Antibiot (Tokyo) Date: 2013-05-29 Impact factor: 2.649

8. An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products.

Authors: Chad W Johnston; Michael A Skinnider; Morgan A Wyatt; Xiang Li; Michael R M Ranieri; Lian Yang; David L Zechel; Bin Ma; Nathan A Magarvey
Journal: Nat Commun Date: 2015-09-28 Impact factor: 14.919

Review 9. Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.

Authors: James S Pham; Karen L Dawson; Katherine E Jackson; Erin E Lim; Charisse Flerida A Pasaje; Kelsey E C Turner; Stuart A Ralph
Journal: Int J Parasitol Drugs Drug Resist Date: 2013-11-11 Impact factor: 4.077

10. Biological Control of Potato Common Scab With Rare Isatropolone C Compound Produced by Plant Growth Promoting Streptomyces A1RT.

Authors: Arslan Sarwar; Zakia Latif; Songya Zhang; Jing Zhu; David L Zechel; Andreas Bechthold
Journal: Front Microbiol Date: 2018-05-30 Impact factor: 5.640