Literature DB >> 7589498

An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase.

M Kron1, K Marquard, M Härtlein, S Price, R Leberman.   

Abstract

Lymphatic filariasis is caused by infection with the filarial nematodes Brugia malayi, Brugia timori, Wuchereria bancrofti and Onchocerca volvulus which collectively infect about 200 million persons throughout the world. Protein sequence homology analysis of a major nematode antigen suggested that it was a class II aminoacyl-tRNA synthetase. The overproduction, purification and verification that the major B. malayi antigen is an asparaginyl-tRNA synthetase is described.

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Year:  1995        PMID： 7589498     DOI： 10.1016/0014-5793(95)01092-s

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid.

Authors:  C Berthet-Colominas; L Seignovert; M Härtlein; M Grotli; S Cusack; R Leberman
Journal:  EMBO J       Date:  1998-05-15       Impact factor: 11.598

2.  Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites.

Authors:  Mostafa E Rateb; Dong Yang; Sanja Vodanovic-Jankovic; Zhiguo Yu; Michael A Kron; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2015-03-04       Impact factor: 2.649

Review 3.  Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

Authors:  Christopher S Francklyn; Patrick Mullen
Journal:  J Biol Chem       Date:  2019-01-22       Impact factor: 5.157

4.  Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change.

Authors:  Sai Chetan K Sukuru; Thibaut Crepin; Youli Milev; Liesl C Marsh; Jonathan B Hill; Regan J Anderson; Jonathan C Morris; Anjali Rohatgi; Gavin O'Mahony; Morten Grøtli; Franck Danel; Malcolm G P Page; Michael Härtlein; Stephen Cusack; Michael A Kron; Leslie A Kuhn
Journal:  J Comput Aided Mol Des       Date:  2006-04-28       Impact factor: 3.686

Review 5.  Leveraging a large microbial strain collection for natural product discovery.

Authors:  Andrew D Steele; Christiana N Teijaro; Dong Yang; Ben Shen
Journal:  J Biol Chem       Date:  2019-09-30       Impact factor: 5.157

6.  Asn-tRNA in Lactobacillus bulgaricus is formed by asparaginylation of tRNA and not by transamidation of Asp-tRNA.

Authors:  S I Kim; M Nalaskowska; J E Germond; D Pridmore; D Söll
Journal:  Nucleic Acids Res       Date:  1996-07-15       Impact factor: 16.971

7.  Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase.

Authors:  Zhiguo Yu; Sanja Vodanovic-Jankovic; Nathan Ledeboer; Sheng-Xiong Huang; Scott R Rajski; Michael Kron; Ben Shen
Journal:  Org Lett       Date:  2011-03-15       Impact factor: 6.005

8.  New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase.

Authors:  Zhiguo Yu; Sanja Vodanovic-Jankovic; Michael Kron; Ben Shen
Journal:  Org Lett       Date:  2012-09-12       Impact factor: 6.005

9.  Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J.

Authors:  Mostafa E Rateb; Zhiguo Yu; Yijun Yan; Dong Yang; Tingting Huang; Sanja Vodanovic-Jankovic; Michael A Kron; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2013-05-29       Impact factor: 2.649

Review 10.  Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.

Authors:  James S Pham; Karen L Dawson; Katherine E Jackson; Erin E Lim; Charisse Flerida A Pasaje; Kelsey E C Turner; Stuart A Ralph
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2013-11-11       Impact factor: 4.077
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