Literature DB >> 26273993

Application of 3D NMR for Structure Determination of Peptide Natural Products.

Fan Zhang1, Navid Adnani1, Emmanuel Vazquez-Rivera2, Doug R Braun1, Marco Tonelli3, David R Andes4, Tim S Bugni1.   

Abstract

Despite the advances in NMR, structure determination is often slow and constitutes a bottleneck in natural products discovery. Removal of this bottleneck would greatly improve the throughput for antibiotic discovery as well as other therapeutic areas. Overall, faster structure methods for structure determination will serve the natural products community in a broad manner. This report describes the first application of 3D NMR for elucidation of two microbially produced peptide natural products with novel structures. The methods are cost-effective and greatly improve the confidence in a proposed structure.

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Year:  2015        PMID： 26273993      PMCID： PMC4696765          DOI： 10.1021/acs.joc.5b01486

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  45 in total

Review 1.  The need for new antibiotics.

Authors:  D M Livermore
Journal:  Clin Microbiol Infect       Date:  2004-11       Impact factor: 8.067

2.  MS/MS networking guided analysis of molecule and gene cluster families.

Authors:  Don Duy Nguyen; Cheng-Hsuan Wu; Wilna J Moree; Anne Lamsa; Marnix H Medema; Xiling Zhao; Ronnie G Gavilan; Marystella Aparicio; Librada Atencio; Chanaye Jackson; Javier Ballesteros; Joel Sanchez; Jeramie D Watrous; Vanessa V Phelan; Corine van de Wiel; Roland D Kersten; Samina Mehnaz; René De Mot; Elizabeth A Shank; Pep Charusanti; Harish Nagarajan; Brendan M Duggan; Bradley S Moore; Nuno Bandeira; Bernhard Ø Palsson; Kit Pogliano; Marcelino Gutiérrez; Pieter C Dorrestein
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-24       Impact factor: 11.205

3.  Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses.

Authors:  M Fellermeier; W Eisenreich; A Bacher; M H Zenk
Journal:  Eur J Biochem       Date:  2001-03

Review 4.  Diversity, abundance and natural products of marine sponge-associated actinomycetes.

Authors:  Usama Ramadan Abdelmohsen; Kristina Bayer; Ute Hentschel
Journal:  Nat Prod Rep       Date:  2014-03       Impact factor: 13.423

5.  Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).

Authors:  S D Bentley; K F Chater; A-M Cerdeño-Tárraga; G L Challis; N R Thomson; K D James; D E Harris; M A Quail; H Kieser; D Harper; A Bateman; S Brown; G Chandra; C W Chen; M Collins; A Cronin; A Fraser; A Goble; J Hidalgo; T Hornsby; S Howarth; C-H Huang; T Kieser; L Larke; L Murphy; K Oliver; S O'Neil; E Rabbinowitsch; M-A Rajandream; K Rutherford; S Rutter; K Seeger; D Saunders; S Sharp; R Squares; S Squares; K Taylor; T Warren; A Wietzorrek; J Woodward; B G Barrell; J Parkhill; D A Hopwood
Journal:  Nature       Date:  2002-05-09       Impact factor: 49.962

6.  Isolation and structure elucidation of cystargamide, a lipopeptide from Kitasatospora cystarginea.

Authors:  Krista A Gill; Fabrice Berrué; Jennifer C Arens; Russell G Kerr
Journal:  J Nat Prod       Date:  2014-06-13       Impact factor: 4.050

7.  Biosynthetic gene cluster of the non-ribosomally synthesized cyclodepsipeptide skyllamycin: deciphering unprecedented ways of unusual hydroxylation reactions.

Authors:  Stefan Pohle; Christian Appelt; Mallorie Roux; Hans-Peter Fiedler; Roderich D Süssmuth
Journal:  J Am Chem Soc       Date:  2011-04-01       Impact factor: 15.419

8.  Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain.

Authors:  Geping Cai; José G Napolitano; James B McAlpine; Yuehong Wang; Birgit U Jaki; Joo-Won Suh; Seung Hwan Yang; In-Ae Lee; Scott G Franzblau; Guido F Pauli; Sanghyun Cho
Journal:  J Nat Prod       Date:  2013-11-13       Impact factor: 4.050

9.  Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery.

Authors:  Michael Poulsen; Dong-Chan Oh; Jon Clardy; Cameron R Currie
Journal:  PLoS One       Date:  2011-02-22       Impact factor: 3.240

10.  Structure and biosynthesis of the antibiotic bottromycin D.

Authors:  Yanpeng Hou; Ma Diarey B Tianero; Jason C Kwan; Thomas P Wyche; Cole R Michel; Gregory A Ellis; Emmanuel Vazquez-Rivera; Doug R Braun; Warren E Rose; Eric W Schmidt; Tim S Bugni
Journal:  Org Lett       Date:  2012-09-17       Impact factor: 6.005
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  4 in total

1.  Progressive Stereo Locking (PSL): A Residual Dipolar Coupling Based Force Field Method for Determining the Relative Configuration of Natural Products and Other Small Molecules.

Authors:  Gabriel Cornilescu; René F Ramos Alvarenga; Thomas P Wyche; Tim S Bugni; Roberto R Gil; Claudia C Cornilescu; William M Westler; John L Markley; Charles D Schwieters
Journal:  ACS Chem Biol       Date:  2017-07-12       Impact factor: 5.100

2.  Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris.

Authors:  Fan Zhang; Kenneth Barns; F Michael Hoffmann; Doug R Braun; David R Andes; Tim S Bugni
Journal:  J Nat Prod       Date:  2017-08-25       Impact factor: 4.050

3.  Bulbiferates A and B: Antibacterial Acetamidohydroxybenzoates from a Marine Proteobacterium, Microbulbifer sp.

Authors:  Dinith R Jayanetti; Doug R Braun; Kenneth J Barns; Scott R Rajski; Tim S Bugni
Journal:  J Nat Prod       Date:  2019-06-04       Impact factor: 4.050

4.  Epoxinnamide: An Epoxy Cinnamoyl-Containing Nonribosomal Peptide from an Intertidal Mudflat-Derived Streptomyces sp.

Authors:  Sangwook Kang; Jaeho Han; Sung Chul Jang; Joon Soo An; Ilnam Kang; Yun Kwon; Sang-Jip Nam; Sang Hee Shim; Jang-Cheon Cho; Sang Kook Lee; Dong-Chan Oh
Journal:  Mar Drugs       Date:  2022-07-12       Impact factor: 6.085
  4 in total

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