Literature DB >> 23489035

Capacity building in anthelmintic drug discovery.

Michael Kron1, Fouad Yousif, Bernadette Ramirez.   

Abstract

International collaboration in anthelmintic drug discovery holds special challenges compared with local or national discovery projects, and at the same time presents the opportunity to build capacity, forge long lasting inter-institutional relationships and strengthen infrastructure in multinational priority areas. This chapter discusses important issues that should be considered in the context of anthelmintic screening centre development and will give examples (Philippines and Egypt) of the productivity of developing country based screening centres. The positive outcomes of infrastructure building is realised in greater capacities for anthelmintic screening at institutions in the countries where the parasitic diseases are endemic and allows for optimum use of specialised resources for public health priority diseases that may be different from those in Western countries. Support for developing country based screening centres also can help countries optimise product development procedures and policies and can facilitate diffusion of desirable technology in corresponding global regions around the world.

Entities:  

Year:  2007        PMID: 23489035     DOI: 10.1517/17460441.2.S1.S75

Source DB:  PubMed          Journal:  Expert Opin Drug Discov        ISSN: 1746-0441            Impact factor:   6.098


  6 in total

1.  Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites.

Authors:  Mostafa E Rateb; Dong Yang; Sanja Vodanovic-Jankovic; Zhiguo Yu; Michael A Kron; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2015-03-04       Impact factor: 2.649

2.  Virtual screening of traditional Chinese medicine (TCM) database: identification of fragment-like lead molecules for filariasis target asparaginyl-tRNA synthetase.

Authors:  Hemant Arya; Mohane Selvaraj Coumar
Journal:  J Mol Model       Date:  2014-05-20       Impact factor: 1.810

3.  Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase.

Authors:  Zhiguo Yu; Sanja Vodanovic-Jankovic; Nathan Ledeboer; Sheng-Xiong Huang; Scott R Rajski; Michael Kron; Ben Shen
Journal:  Org Lett       Date:  2011-03-15       Impact factor: 6.005

4.  New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase.

Authors:  Zhiguo Yu; Sanja Vodanovic-Jankovic; Michael Kron; Ben Shen
Journal:  Org Lett       Date:  2012-09-12       Impact factor: 6.005

5.  Effectiveness of Repeated Administration of Praziquantel with Disodium Glycyrrhizinate and Two Enantiomers of Praziquantel on Opisthorchis felineus (Rivolta, 1884).

Authors:  D F Avgustinovich; M A Tsyganov; M Y Pakharukova; E N Chulakov; A V Dushkin; V P Krasnov; V A Mordvinov
Journal:  Acta Parasitol       Date:  2019-12-03       Impact factor: 1.440

6.  In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi.

Authors:  David Wenkert; Bernadette Ramirez; Yuehai Shen; Michael A Kron
Journal:  J Parasitol Res       Date:  2010-12-29
  6 in total

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