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Literature DB >> 22964247

KPC-9, a novel carbapenemase from clinical specimens in Israel.

Carlos Hidalgo-Grass¹, Gabriela Warburg, Violeta Temper, Shmuel Benenson, Allon E Moses, Colin Block, Jacob Strahilevitz.

Abstract

A bla(KPC-9) carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from bla(KPC-3) by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. bla(KPC-9) was found on a plasmid indistinguishable from pKpQIL that carries bla(KPC-3) in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22964247 PMCID： PMC3486598 DOI： 10.1128/AAC.01156-12

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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Journal: J Antimicrob Chemother Date: 2012-01-26 Impact factor: 5.790

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Review 6. Emerging and re-emerging infectious disease in otorhinolaryngology.

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7. Horizontal Transfer of Carbapenemase-Encoding Plasmids and Comparison with Hospital Epidemiology Data.

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8. Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability.

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Review 9. Optimizing antimicrobial therapy in critically ill patients.

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Review 10. Epidemiology of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries.

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