Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing beta-lactamase.

Literature DB >> 16251324

Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing beta-lactamase.

Jimena Alba¹, Yoshikazu Ishii, Kenneth Thomson, Ellen Smith Moland, Keizo Yamaguchi.

Abstract

The kinetic activity of KPC-3, a plasmid-encoded class A carbapenemase, was studied. It hydrolyzed penicillins, cephalosporins, carbapenems, and even sulbactam. The best substrate was cephalothin (k(cat/K)m = 3.48 microM(-1) s(-1)). The efficiency of the enzyme was similar for imipenem and meropenem (k(cat)/K(m), 1.4 and 1.94 microM(-1) s(-1), respectively).

Entities: Chemical

Mesh：

Substances：

Year: 2005 PMID： 16251324 PMCID： PMC1280115 DOI： 10.1128/AAC.49.11.4760-4762.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

30 in total

Review 1. Important and emerging beta-lactamase-mediated resistances in hospital-based pathogens: the Amp C enzymes.

Authors: R N Jones
Journal: Diagn Microbiol Infect Dis Date: 1998-07 Impact factor: 2.803

2. Biochemical characterization of a beta-lactamase that hydrolyzes penems and carbapenems from two Serratia marcescens isolates.

Authors: Y J Yang; P J Wu; D M Livermore
Journal: Antimicrob Agents Chemother Date: 1990-05 Impact factor: 5.191

3. Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae.

Authors: B A Rasmussen; K Bush; D Keeney; Y Yang; R Hare; C O'Gara; A A Medeiros
Journal: Antimicrob Agents Chemother Date: 1996-09 Impact factor: 5.191

Review 4. A functional classification scheme for beta-lactamases and its correlation with molecular structure.

Authors: K Bush; G A Jacoby; A A Medeiros
Journal: Antimicrob Agents Chemother Date: 1995-06 Impact factor: 5.191

5. Mechanisms responsible for reduced susceptibility to imipenem in Bacteroides fragilis.

Authors: R Edwards; D Greenwood
Journal: J Antimicrob Chemother Date: 1996-12 Impact factor: 5.790

6. Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.

Authors: Sofia Vourli; Panagiota Giakkoupi; Vivi Miriagou; Eva Tzelepi; Alkiviadis C Vatopoulos; Leonidas S Tzouvelekis
Journal: FEMS Microbiol Lett Date: 2004-05-15 Impact factor: 2.742

7. Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City.

Authors: Patricia A Bradford; Simona Bratu; Carl Urban; Melissa Visalli; Noriel Mariano; David Landman; James J Rahal; Steven Brooks; Sanda Cebular; John Quale
Journal: Clin Infect Dis Date: 2004-06-14 Impact factor: 9.079

8. Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.

Authors: Hesna Yigit; Anne Marie Queenan; J Kamile Rasheed; James W Biddle; Antonio Domenech-Sanchez; Sebastian Alberti; Karen Bush; Fred C Tenover
Journal: Antimicrob Agents Chemother Date: 2003-12 Impact factor: 5.191

9. Molecular characterization of a carbapenem-hydrolyzing class A beta-lactamase, SFC-1, from Serratia fonticola UTAD54.

Authors: Isabel Henriques; Alexandra Moura; Artur Alves; Maria José Saavedra; António Correia
Journal: Antimicrob Agents Chemother Date: 2004-06 Impact factor: 5.191

10. Biochemical properties of a carbapenem-hydrolyzing beta-lactamase from Enterobacter cloacae and cloning of the gene into Escherichia coli.

Authors: P Nordmann; S Mariotte; T Naas; R Labia; M H Nicolas
Journal: Antimicrob Agents Chemother Date: 1993-05 Impact factor: 5.191

30 in total

1. Characteristics of meropenem heteroresistance in Klebsiella pneumoniae carbapenemase (KPC)-producing clinical isolates of K. pneumoniae.

Authors: Spyros Pournaras; Ioulia Kristo; Georgia Vrioni; Alexandros Ikonomidis; Aggeliki Poulou; Dimitra Petropoulou; Athanassios Tsakris
Journal: J Clin Microbiol Date: 2010-05-26 Impact factor: 5.948

Review 2. Carbapenemases: the versatile beta-lactamases.

Authors: Anne Marie Queenan; Karen Bush
Journal: Clin Microbiol Rev Date: 2007-07 Impact factor: 26.132

3. bla(KPC) RNA expression correlates with two transcriptional start sites but not always with gene copy number in four genera of Gram-negative pathogens.

Authors: Amanda L Roth; Philip M Kurpiel; Philip D Lister; Nancy D Hanson
Journal: Antimicrob Agents Chemother Date: 2011-05-16 Impact factor: 5.191

4. Microbiological and Genetic Characterization of Carbapenem-Resistant Klebsiella pneumoniae Isolated From Pediatric Patients.

Authors: Jasmeen S Dara; Liang Chen; Michael H Levi; Barry N Kreiswirth; Rebecca Pellett Madan
Journal: J Pediatric Infect Dis Soc Date: 2013-08-20 Impact factor: 3.164

5. Exploring the role of a conserved class A residue in the Ω-Loop of KPC-2 β-lactamase: a mechanism for ceftazidime hydrolysis.

Authors: Peter S Levitt; Krisztina M Papp-Wallace; Magdalena A Taracila; Andrea M Hujer; Marisa L Winkler; Kerri M Smith; Yan Xu; Michael E Harris; Robert A Bonomo
Journal: J Biol Chem Date: 2012-07-26 Impact factor: 5.157

Review 6. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions.

Authors: L S Tzouvelekis; A Markogiannakis; M Psichogiou; P T Tassios; G L Daikos
Journal: Clin Microbiol Rev Date: 2012-10 Impact factor: 26.132

7. Direct detection and genotyping of Klebsiella pneumoniae carbapenemases from urine by use of a new DNA microarray test.

Authors: Harald Peter; Kathrine Berggrav; Peter Thomas; Yvonne Pfeifer; Wolfgang Witte; Kate Templeton; Till T Bachmann
Journal: J Clin Microbiol Date: 2012-10-03 Impact factor: 5.948