Literature DB >> 22951899

A strategy to enhance the binding affinity of fluorophore-aptamer pairs for RNA tagging with neomycin conjugation.

Jongho Jeon1, Kyung Hyun Lee, Jianghong Rao.   

Abstract

Fluorogenic sulforhodamine-neomycin conjugates have been designed and synthesized for RNA tagging. Conjugates were fluorescently activated by binding to RNA aptamers and exhibited greater than 250-400 fold enhancement in binding affinity relative to corresponding unconjugated fluorophores.

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Year:  2012        PMID： 22951899      PMCID： PMC3728288          DOI： 10.1039/c2cc34498j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  26 in total

1.  Hairpin DNA-functionalized gold colloids for the imaging of mRNA in live cells.

Authors:  Ashwath Jayagopal; Kristin C Halfpenny; Jonas W Perez; David W Wright
Journal:  J Am Chem Soc       Date:  2010-07-21       Impact factor: 15.419

Review 2.  New approaches toward recognition of nucleic acid triple helices.

Authors:  Dev P Arya
Journal:  Acc Chem Res       Date:  2010-11-12       Impact factor: 22.384

3.  LambdaN-GFP: an RNA reporter system for live-cell imaging.

Authors:  Nathalie Daigle; Jan Ellenberg
Journal:  Nat Methods       Date:  2007-07-01       Impact factor: 28.547

Review 4.  Imaging intracellular RNA distribution and dynamics in living cells.

Authors:  Sanjay Tyagi
Journal:  Nat Methods       Date:  2009-05       Impact factor: 28.547

5.  Transcription monitoring using fused RNA with a dye-binding light-up aptamer as a tag: a blue fluorescent RNA.

Authors:  Shinsuke Sando; Atsushi Narita; Masayoshi Hayami; Yasuhiro Aoyama
Journal:  Chem Commun (Camb)       Date:  2008-07-24       Impact factor: 6.222

6.  Small-molecule fluorescent probes for specific RNA targets.

Authors:  Asako Murata; Shin-ichi Sato; Yoshinori Kawazoe; Motonari Uesugi
Journal:  Chem Commun (Camb)       Date:  2011-03-17       Impact factor: 6.222

7.  Fluorescent sensors for specific RNA: a general paradigm using chemistry and combinatorial biology.

Authors:  Brian A Sparano; Kazunori Koide
Journal:  J Am Chem Soc       Date:  2007-03-27       Impact factor: 15.419

8.  Synthesis and spectroscopic studies of the aminoglycoside (neomycin)--perylene conjugate binding to human telomeric DNA.

Authors:  Liang Xue; Nihar Ranjan; Dev P Arya
Journal:  Biochemistry       Date:  2011-03-17       Impact factor: 3.162

9.  Combining SELEX screening and rational design to develop light-up fluorophore-RNA aptamer pairs for RNA tagging.

Authors:  Jungjoon Lee; Kyung Hyun Lee; Jongho Jeon; Anca Dragulescu-Andrasi; Fei Xiao; Jianghong Rao
Journal:  ACS Chem Biol       Date:  2010-11-19       Impact factor: 5.100

Review 10.  Fluorescent probes for live-cell RNA detection.

Authors:  Gang Bao; Won Jong Rhee; Andrew Tsourkas
Journal:  Annu Rev Biomed Eng       Date:  2009       Impact factor: 9.590
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