OBJECTIVE: Bone marrow lesions (BMLs) are a common magnetic resonance (MR) feature in patients with osteoarthritis, however their pathological basis remains poorly understood and has not been evaluated in vivo. Our aim was to evaluate the trabecular structure associated with the presence and size of BMLs present in the same regions of interest (ROI) using quantitative MR-based trabecular morphometry. DESIGN: 158 participants in the Osteoarthritis Initiative (OAI) were imaged with a coronal 3D fast imaging with steady state precession (FISP) sequence for trabecular morphometry in the same session as the OAI 3 T MR knee evaluation. The proximal medial tibial subchondral bone in the central weight-bearing ROI on these knee 3D FISP images were quantitatively evaluated for apparent bone volume fraction, trabecular number, spacing, and thickness. BMLs were also evaluated in the subchondral bone immediately adjacent to the articular cartilage. BML volume was also evaluated within the same trabecular morphometry ROI and semi-quantitatively classified as none, small, or large. Kruskal-Wallis test was used to determine if mean apparent bone volume fraction, trabecular number, spacing, or thickness differed by BML score. RESULTS: Compared to knees with ROIs containing no BMLs, knees with small or large BMLs had statistically higher apparent bone volume fraction (P < 0.01), trabecular number (P < 0.01), and thickness (P = 0.02), and lower trabecular spacing (P < 0.01). CONCLUSIONS: Compared to knees with ROIs containing no BMLs, knees with ROIs containing small or large BMLs had higher apparent bone volume fraction, trabecular number and thickness, but lower trabecular spacing. These findings may represent areas of locally increased bone remodeling or compression.
OBJECTIVE:Bone marrow lesions (BMLs) are a common magnetic resonance (MR) feature in patients with osteoarthritis, however their pathological basis remains poorly understood and has not been evaluated in vivo. Our aim was to evaluate the trabecular structure associated with the presence and size of BMLs present in the same regions of interest (ROI) using quantitative MR-based trabecular morphometry. DESIGN: 158 participants in the Osteoarthritis Initiative (OAI) were imaged with a coronal 3D fast imaging with steady state precession (FISP) sequence for trabecular morphometry in the same session as the OAI 3 T MR knee evaluation. The proximal medial tibial subchondral bone in the central weight-bearing ROI on these knee 3D FISP images were quantitatively evaluated for apparent bone volume fraction, trabecular number, spacing, and thickness. BMLs were also evaluated in the subchondral bone immediately adjacent to the articular cartilage. BML volume was also evaluated within the same trabecular morphometry ROI and semi-quantitatively classified as none, small, or large. Kruskal-Wallis test was used to determine if mean apparent bone volume fraction, trabecular number, spacing, or thickness differed by BML score. RESULTS: Compared to knees with ROIs containing no BMLs, knees with small or large BMLs had statistically higher apparent bone volume fraction (P < 0.01), trabecular number (P < 0.01), and thickness (P = 0.02), and lower trabecular spacing (P < 0.01). CONCLUSIONS: Compared to knees with ROIs containing no BMLs, knees with ROIs containing small or large BMLs had higher apparent bone volume fraction, trabecular number and thickness, but lower trabecular spacing. These findings may represent areas of locally increased bone remodeling or compression.
Authors: F Eckstein; G Ateshian; R Burgkart; D Burstein; F Cicuttini; B Dardzinski; M Gray; T M Link; S Majumdar; T Mosher; C Peterfy; S Totterman; J Waterton; C S Winalski; D Felson Journal: Osteoarthritis Cartilage Date: 2006-05-26 Impact factor: 6.576
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Authors: A A Guccione; D T Felson; J J Anderson; J M Anthony; Y Zhang; P W Wilson; M Kelly-Hayes; P A Wolf; B E Kreger; W B Kannel Journal: Am J Public Health Date: 1994-03 Impact factor: 9.308
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Authors: Jeffrey B Driban; Lori Price; Grace H Lo; Jincheng Pang; David J Hunter; Eric Miller; Robert J Ward; Charles B Eaton; John A Lynch; Timothy E McAlindon Journal: Arthritis Res Ther Date: 2013 Impact factor: 5.156
Authors: Jeffrey B Driban; Grace H Lo; Lori Price; Jincheng Pang; Eric Miller; Robert J Ward; David J Hunter; Charles B Eaton; John A Lynch; Timothy E McAlindon Journal: Arthritis Res Ther Date: 2013 Impact factor: 5.156
Authors: Jeffrey B Driban; Mary F Barbe; Mamta Amin; Neil S Kalariya; Ming Zhang; Grace H Lo; Anna M Tassinari; Daniel Harper; Lori Lyn Price; Charles B Eaton; Erika Schneider; Timothy E McAlindon Journal: BMC Musculoskelet Disord Date: 2014-04-29 Impact factor: 2.362
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