OBJECTIVE: To examine the relationship between structural changes of trabecular bone and cartilage, in patients with varying degrees of osteoarthritis (OA) over 2 years, using magnetic resonance imaging. METHODS: High-resolution, axial images were acquired for assessing trabecular bone structure, using a 3-D fast gradient-echo sequence. High-resolution, fat-suppressed, sagittal images were acquired for assessing cartilage structure, using a 3-D spoiled gradient-echo sequence. In a subset of the patients, sagittal images were acquired for measuring T(2) relaxation time, using a 2-D dual-echo spin echo sequence. RESULTS: A large variation in bone and cartilage parameters is evident among individual subjects in each group, however, group-specific means demonstrate decreasing trends (in bone and cartilage parameters) in osteoarthritic subjects (especially in mild OA subjects). The mean T(2) increased significantly (P<0.05) between the baseline and follow-up exams for all cartilage compartments except the lateral tibia. A positive relationship was established between cartilage changes and localized bone changes closest to the joint line, while a negative relationship was established between cartilage changes and global bone changes farthest from the joint line. CONCLUSION: This study quantifies the changes in bone and cartilage structural parameters over time, and demonstrates a longitudinal relationship between the morphological changes in bone and cartilage structure in patients with varying degrees of OA. Although a large variation of bone and cartilage changes is apparent among subjects, significant trends are evident in a relatively small sample size, with a short follow-up duration.
OBJECTIVE: To examine the relationship between structural changes of trabecular bone and cartilage, in patients with varying degrees of osteoarthritis (OA) over 2 years, using magnetic resonance imaging. METHODS: High-resolution, axial images were acquired for assessing trabecular bone structure, using a 3-D fast gradient-echo sequence. High-resolution, fat-suppressed, sagittal images were acquired for assessing cartilage structure, using a 3-D spoiled gradient-echo sequence. In a subset of the patients, sagittal images were acquired for measuring T(2) relaxation time, using a 2-D dual-echo spin echo sequence. RESULTS: A large variation in bone and cartilage parameters is evident among individual subjects in each group, however, group-specific means demonstrate decreasing trends (in bone and cartilage parameters) in osteoarthritic subjects (especially in mild OA subjects). The mean T(2) increased significantly (P<0.05) between the baseline and follow-up exams for all cartilage compartments except the lateral tibia. A positive relationship was established between cartilage changes and localized bone changes closest to the joint line, while a negative relationship was established between cartilage changes and global bone changes farthest from the joint line. CONCLUSION: This study quantifies the changes in bone and cartilage structural parameters over time, and demonstrates a longitudinal relationship between the morphological changes in bone and cartilage structure in patients with varying degrees of OA. Although a large variation of bone and cartilage changes is apparent among subjects, significant trends are evident in a relatively small sample size, with a short follow-up duration.
Authors: James R Pinney; Carmen Taylor; Ryan Doan; Andrew J Burghardt; Xiaojuan Li; Hubert T Kim; C Benjamin Ma; Sharmila Majumdar Journal: Magn Reson Imaging Date: 2011-11-08 Impact factor: 2.546
Authors: G B Joseph; T Baum; H Alizai; J Carballido-Gamio; L Nardo; W Virayavanich; J A Lynch; M C Nevitt; C E McCulloch; S Majumdar; T M Link Journal: Osteoarthritis Cartilage Date: 2012-04-11 Impact factor: 6.576
Authors: G H Lo; A M Tassinari; J B Driban; L L Price; E Schneider; S Majumdar; T E McAlindon Journal: Osteoarthritis Cartilage Date: 2012-03-16 Impact factor: 6.576
Authors: Gregory Chang; S Kubilay Pakin; Mark E Schweitzer; Punam K Saha; Ravinder R Regatte Journal: J Magn Reson Imaging Date: 2008-05 Impact factor: 4.813
Authors: Alexandra S Gersing; Pia M Jungmann; Benedikt J Schwaiger; Julia Zarnowski; Felix K Kopp; Saskia Landwehr; Martin Sauerschnig; Gabby B Joseph; Andreas B Imhoff; Ernst J Rummeny; Jan S Kirschke; Thomas Baum Journal: J ISAKOS Date: 2018-06-28
Authors: R I Bolbos; Jin Zuo; Suchandrima Banerjee; Thomas M Link; C Benjamin Ma; Xiaojuan Li; Sharmila Majumdar Journal: Osteoarthritis Cartilage Date: 2008-04-02 Impact factor: 6.576