BACKGROUND: Multiple studies have reported associations between the PSCA rs2294008 C>T polymorphism and GC, but susceptibility has proven inconsistent. Therefore, we estimates the relationship between the rs2294008 C>T polymorphism and GC by meta-analysis. METHODS: PubMed, Embase and Web of Science databases were searched and nine independent case-control studies were included in this meta- analysis. Crude ORs with 95% CIs were extracted according to the Mantal-Haenszel method and pooled to assess the strength of the association. RESULTS: We observed that the PSCA rs2294008 C>T polymorphism was significantly correlated with GC risk when all studies were pooled into the meta-analysis. Further subgroup analysis showed the polymorphism to be linked with diffuse and noncardia GC in the allele contrast model, homozygote codominant model, dominant model, and recessive model. However, no connection was apparent for intestinal and cardia GC. In the stratified analysis by ethnicity, significant associations were observed in Asians for the recessive model. Interestingly, the relationship was particularly significant in the Chinese population. CONCLUSIONS: Our findings suggest that the PSCA rs2294008 C>T polymorphism is a risk factor for GC, especially in diffuse and noncardia GC and in Chinese.
BACKGROUND: Multiple studies have reported associations between the PSCArs2294008 C>T polymorphism and GC, but susceptibility has proven inconsistent. Therefore, we estimates the relationship between the rs2294008 C>T polymorphism and GC by meta-analysis. METHODS: PubMed, Embase and Web of Science databases were searched and nine independent case-control studies were included in this meta- analysis. Crude ORs with 95% CIs were extracted according to the Mantal-Haenszel method and pooled to assess the strength of the association. RESULTS: We observed that the PSCArs2294008 C>T polymorphism was significantly correlated with GC risk when all studies were pooled into the meta-analysis. Further subgroup analysis showed the polymorphism to be linked with diffuse and noncardia GC in the allele contrast model, homozygote codominant model, dominant model, and recessive model. However, no connection was apparent for intestinal and cardia GC. In the stratified analysis by ethnicity, significant associations were observed in Asians for the recessive model. Interestingly, the relationship was particularly significant in the Chinese population. CONCLUSIONS: Our findings suggest that the PSCArs2294008 C>T polymorphism is a risk factor for GC, especially in diffuse and noncardia GC and in Chinese.