| Literature DB >> 22920243 |
Margaret E Teasdale1, Tonya L Shearer, Sebastian Engel, Troy S Alexander, Craig R Fairchild, Jacques Prudhomme, Manuel Torres, Karine Le Roch, William Aalbersberg, Mark E Hay, Julia Kubanek.
Abstract
Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.Entities:
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Year: 2012 PMID： 22920243 PMCID： PMC3474338 DOI： 10.1021/jo301246x
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354