Literature DB >> 19053716

Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia.

E Paige Stout1, Adam P Hasemeyer, Amy L Lane, Theresa M Davenport, Sebastian Engel, Mark E Hay, Craig R Fairchild, Jacques Prudhomme, Karine Le Roch, William Aalbersberg, Julia Kubanek.   

Abstract

Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).

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Year:  2009        PMID： 19053716      PMCID： PMC2646105          DOI： 10.1021/ol8024814

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

Review 1.  Marine natural products.

Authors:  John W Blunt; Brent R Copp; Wan-Ping Hu; Murray H G Munro; Peter T Northcote; Michèle R Prinsep
Journal:  Nat Prod Rep       Date:  2008-01-03       Impact factor: 13.423

2.  Biosynthesis of polyunsaturated fatty acids by polyketide synthases.

Authors:  Ursula Kaulmann; Christian Hertweck
Journal:  Angew Chem Int Ed Engl       Date:  2002-06-03       Impact factor: 15.336

Review 3.  2-Pyrone natural products and mimetics: isolation, characterisation and biological activity.

Authors:  Gerard P McGlacken; Ian J S Fairlamb
Journal:  Nat Prod Rep       Date:  2005-05-05       Impact factor: 13.423

4.  Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes.

Authors:  J G Metz; P Roessler; D Facciotti; C Levering; F Dittrich; M Lassner; R Valentine; K Lardizabal; F Domergue; A Yamada; K Yazawa; V Knauf; J Browse
Journal:  Science       Date:  2001-07-13       Impact factor: 47.728
  4 in total
  12 in total

1.  Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.

Authors:  Alberto Plaza; Jessica L Keffer; Giuseppe Bifulco; John R Lloyd; Carole A Bewley
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

2.  Bromophycoic acids: bioactive natural products from a Fijian red alga Callophycus sp.

Authors:  Margaret E Teasdale; Tonya L Shearer; Sebastian Engel; Troy S Alexander; Craig R Fairchild; Jacques Prudhomme; Manuel Torres; Karine Le Roch; William Aalbersberg; Mark E Hay; Julia Kubanek
Journal:  J Org Chem       Date:  2012-09-05       Impact factor: 4.354

3.  Seaweed allelopathy against coral: surface distribution of a seaweed secondary metabolite by imaging mass spectrometry.

Authors:  Tiffany D Andras; Troy S Alexander; Asiri Gahlena; R Mitchell Parry; Facundo M Fernandez; Julia Kubanek; May D Wang; Mark E Hay
Journal:  J Chem Ecol       Date:  2012-10-30       Impact factor: 2.626

Review 4.  Algal Toxic Compounds and Their Aeroterrestrial, Airborne and other Extremophilic Producers with Attention to Soil and Plant Contamination: A Review.

Authors:  Georg Gӓrtner; Maya Stoyneva-Gӓrtner; Blagoy Uzunov
Journal:  Toxins (Basel)       Date:  2021-04-29       Impact factor: 4.546

5.  Anti-phytopathogenic activities of macro-algae extracts.

Authors:  Edra Jiménez; Fernando Dorta; Cristian Medina; Alberto Ramírez; Ingrid Ramírez; Hugo Peña-Cortés
Journal:  Mar Drugs       Date:  2011-05-03       Impact factor: 6.085

6.  High content live cell imaging for the discovery of new antimalarial marine natural products.

Authors:  Serena Cervantes; Paige E Stout; Jacques Prudhomme; Sebastian Engel; Matthew Bruton; Michael Cervantes; David Carter; Young Tae-Chang; Mark E Hay; William Aalbersberg; Julia Kubanek; Karine G Le Roch
Journal:  BMC Infect Dis       Date:  2012-01-03       Impact factor: 3.090

Review 7.  Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2013-07-16       Impact factor: 5.118

Review 8.  Recent advances in the synthesis of 2-pyrones.

Authors:  Jong Seok Lee
Journal:  Mar Drugs       Date:  2015-03-23       Impact factor: 5.118

9.  Pyran Rings Containing Polyketides from Penicillium raistrickii.

Authors:  Li-Ying Ma; De-Sheng Liu; De-Guo Li; Yu-Ling Huang; Hui-Hui Kang; Chun-Hua Wang; Wei-Zhong Liu
Journal:  Mar Drugs       Date:  2016-12-23       Impact factor: 5.118

10.  Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides.

Authors:  Sofia-Eléna Motuhi; Omid Feizbakhsh; Béatrice Foll-Josselin; Blandine Baratte; Claire Delehouzé; Arnaud Cousseau; Xavier Fant; Jeannette Chloë Bulinski; Claude Elisabeth Payri; Sandrine Ruchaud; Mohamed Mehiri; Stéphane Bach
Journal:  Mar Drugs       Date:  2019-02-01       Impact factor: 5.118
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