Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Comparative genomic analysis of eutherian interferon-γ-inducible GTPases.

Literature DB >> 22892676

Comparative genomic analysis of eutherian interferon-γ-inducible GTPases.

Abstract

The interferon-γ-inducible GTPases, IFGGs, are intracellular proteins involved in immune response against pathogens. A comprehensive comparative genomic review and analysis of eutherian IFGGs was carried out using public genomic sequences. The 64 eutherian IFGG genes were examined in detail and annotated. The eutherian IFGG promoter types were first catalogued followed by a phylogenetic analysis of eutherian IFGGs, which described five major IFGG clusters. The patterns of differential gene expansions and protein regions that may regulate IFGG catalytic features suggested a new classification of eutherian IFGGs. This mini-review has also provided new tests of reliability of public genomic sequences as well as tests of protein molecular evolution.

Mesh：

Substances：

Year: 2012 PMID： 22892676 DOI： 10.1007/s10142-012-0291-2

Source DB: PubMed Journal: Funct Integr Genomics ISSN： 1438-793X Impact factor: 3.410

31 in total

1. Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases.

Authors: Agnidipta Ghosh; Revathy Uthaiah; Jonathan Howard; Christian Herrmann; Eva Wolf
Journal: Mol Cell Date: 2004-09-10 Impact factor: 17.970

2. Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.

Authors: G A Taylor; C M Collazo; G S Yap; K Nguyen; T A Gregorio; L S Taylor; B Eagleson; L Secrest; E A Southon; S W Reid; L Tessarollo; M Bray; D W McVicar; K L Komschlies; H A Young; C A Biron; A Sher; G F Vande Woude
Journal: Proc Natl Acad Sci U S A Date: 2000-01-18 Impact factor: 11.205

3. The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates.

Authors: Guang Li; Juyong Zhang; Yi Sun; Hua Wang; Yiquan Wang
Journal: Mol Biol Evol Date: 2009-04-15 Impact factor: 16.240

Review 4. The IRG proteins: a function in search of a mechanism.

Authors: Jonathan Howard
Journal: Immunobiology Date: 2007-12-31 Impact factor: 3.144

5. The IRG-47 gene is IFN-gamma induced in B cells and encodes a protein with GTP-binding motifs.

Authors: M Gilly; R Wall
Journal: J Immunol Date: 1992-05-15 Impact factor: 5.422

6. Regulation of macrophage motility by Irgm1.

Authors: Stanley C Henry; Maria Traver; Xiaojou Daniell; Maanasa Indaram; Tim Oliver; Gregory A Taylor
Journal: J Leukoc Biol Date: 2009-11-17 Impact factor: 4.962

7. Human IRGM induces autophagy to eliminate intracellular mycobacteria.

Authors: Sudha B Singh; Alexander S Davis; Gregory A Taylor; Vojo Deretic
Journal: Science Date: 2006-08-03 Impact factor: 47.728

8. Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein.

Authors: W P Lafuse; D Brown; L Castle; B S Zwilling
Journal: J Leukoc Biol Date: 1995-03 Impact factor: 4.962

9. Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes.

Authors: Roderic Guigo; Emmanouil T Dermitzakis; Pankaj Agarwal; Chris P Ponting; Genis Parra; Alexandre Reymond; Josep F Abril; Evan Keibler; Robert Lyle; Catherine Ucla; Stylianos E Antonarakis; Michael R Brent
Journal: Proc Natl Acad Sci U S A Date: 2003-01-27 Impact factor: 11.205

10. Isolation of a gene encoding a developmentally regulated T cell-specific protein with a guanine nucleotide triphosphate-binding motif.

Authors: D A Carlow; J Marth; I Clark-Lewis; H S Teh
Journal: J Immunol Date: 1995-02-15 Impact factor: 5.422

3 in total