Literature DB >> 16888103

Human IRGM induces autophagy to eliminate intracellular mycobacteria.

Sudha B Singh1, Alexander S Davis, Gregory A Taylor, Vojo Deretic.   

Abstract

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16888103     DOI： 10.1126/science.1129577

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  404 in total

1.  Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis.

Authors:  Andrew A Maynard; Katerina Dvorak; Ludmila Khailova; Holly Dobrenen; Kelly M Arganbright; Melissa D Halpern; Ashish R Kurundkar; Akhil Maheshwari; Bohuslav Dvorak
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-06-10       Impact factor: 4.052

Review 2.  Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.

Authors:  Amrita Kabi; Kourtney P Nickerson; Craig R Homer; Christine McDonald
Journal:  Inflamm Bowel Dis       Date:  2011-09-20       Impact factor: 5.325

3.  IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis.

Authors:  Shui Ping Tu; Michael Quante; Govind Bhagat; Shigeo Takaishi; Guanglin Cui; Xiang Dong Yang; Sureshkumar Muthuplani; Wataru Shibata; James G Fox; D Mark Pritchard; Timothy C Wang
Journal:  Cancer Res       Date:  2011-04-21       Impact factor: 12.701

Review 4.  Autophagy: a primer for the gastroenterologist/hepatologist.

Authors:  Christiane Sokollik; Michelle Ang; Nicola Jones
Journal:  Can J Gastroenterol       Date:  2011-12       Impact factor: 3.522

5.  The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.

Authors:  Matthias Prager; Janine Büttner; Verena Haas; Daniel C Baumgart; Andreas Sturm; Martin Zeitz; Carsten Büning
Journal:  Int J Colorectal Dis       Date:  2011-11-09       Impact factor: 2.571

6.  A comprehensive glossary of autophagy-related molecules and processes (2nd edition).

Authors:  Daniel J Klionsky; Eric H Baehrecke; John H Brumell; Charleen T Chu; Patrice Codogno; Ana Marie Cuervo; Jayanta Debnath; Vojo Deretic; Zvulun Elazar; Eeva-Liisa Eskelinen; Steven Finkbeiner; Juan Fueyo-Margareto; David Gewirtz; Marja Jäättelä; Guido Kroemer; Beth Levine; Thomas J Melia; Noboru Mizushima; David C Rubinsztein; Anne Simonsen; Andrew Thorburn; Michael Thumm; Sharon A Tooze
Journal:  Autophagy       Date:  2011-11-01       Impact factor: 16.016

Review 7.  Crohn disease: a current perspective on genetics, autophagy and immunity.

Authors:  Thaddeus S Stappenbeck; John D Rioux; Atsushi Mizoguchi; Tatsuya Saitoh; Alan Huett; Arlette Darfeuille-Michaud; Tom Wileman; Noboru Mizushima; Simon Carding; Shizuo Akira; Miles Parkes; Ramnik J Xavier
Journal:  Autophagy       Date:  2011-04-01       Impact factor: 16.016

Review 8.  Autophagy in innate and adaptive immunity.

Authors:  Yi Xu; N Tony Eissa
Journal:  Proc Am Thorac Soc       Date:  2010-02

9.  Balance of Irgm protein activities determines IFN-gamma-induced host defense.

Authors:  Stanley C Henry; Xiaoju G Daniell; Ashley R Burroughs; Maanasa Indaram; David N Howell; Jörn Coers; Michael N Starnbach; Julia P Hunn; Jonathan C Howard; Carl G Feng; Alan Sher; Gregory A Taylor
Journal:  J Leukoc Biol       Date:  2009-01-27       Impact factor: 4.962

Review 10.  Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease.

Authors:  Arthur Kaser; Richard S Blumberg
Journal:  Semin Immunol       Date:  2009-02-23       Impact factor: 11.130
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.