| Literature DB >> 10639151 |
G A Taylor1, C M Collazo, G S Yap, K Nguyen, T A Gregorio, L S Taylor, B Eagleson, L Secrest, E A Southon, S W Reid, L Tessarollo, M Bray, D W McVicar, K L Komschlies, H A Young, C A Biron, A Sher, G F Vande Woude.
Abstract
Interferon-gamma (IFN-gamma) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of IFN-gamma-regulated genes that encode 48-kDa GTP-binding proteins that localize to the endoplasmic reticulum. We have generated IGTP-deficient mice and found that, despite normal immune cell development and normal clearance of Listeria monocytogenes and cytomegalovirus infections, the mice displayed a profound loss of host resistance to acute infections of the protozoan parasite Toxoplasma gondii. By contrast, IFN-gamma receptor-deficient mice have increased susceptibility to all three pathogens. Thus, IGTP defines an IFN-gamma-regulated pathway with a specialized role in antimicrobial resistance.Entities:
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Year: 2000 PMID： 10639151 PMCID： PMC15402 DOI： 10.1073/pnas.97.2.751
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205