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Literature DB >> 24337645

Comparative genomic analysis of eutherian ribonuclease A genes.

Abstract

The present study attempted to update comprehensive eutherian ribonuclease A gene data sets, using public eutherian genomic sequence data sets and new genomics and molecular evolution tests. Among 448 ribonuclease A potential coding sequences, the present analysis annotated 255 complete coding sequences. The most comprehensive data set of eutherian ribonuclease A genes first characterized 13 major gene clusters, 9 of which showed evidence of differential gene expansions. In addition, the present analysis described common predicted promoter regions of eutherian ribonuclease A genes. The present study also attempted to resolve discrepancies in descriptions of eutherian ribonuclease A genes. Thus, the integrated gene annotations, phylogenetic analysis and protein molecular evolution analysis proposed new classification and nomenclature of eutherian ribonuclease A genes, as new framework of future experiments.

Mesh：

Substances：
Ribonuclease, Pancreatic

Year: 2013 PMID： 24337645 DOI： 10.1007/s00438-013-0801-5

Source DB: PubMed Journal: Mol Genet Genomics ISSN： 1617-4623 Impact factor: 3.291

25 in total

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