Literature DB >> 2286806

Flow cytometric analysis in colorectal carcinoma: prognostic significance of cellular DNA content.

A Schillaci1, D D Tirindelli, M Ferri, L Teodori, F Mauro, V Nicolanti, S Stipa.   

Abstract

The prognostic value of DNA ploidy status was evaluated prospectively in 70 patients with colorectal carcinoma. Cellular DNA content was measured by flow cytometry from fresh specimens with multiple site sampling. Seventy-five percent of cases exhibited a DNA aneuploid pattern. In a univariate analysis, DNA ploidy status showed a statistically significant correlation with survival (p less than 0.05), weaker than Dukes' stage (p less than 0.001). No correlation was observed between survival and presence of multiple DNA stemlines. In a multivariate analysis, Dukes' stage was the strongest prognostic indicator (p = 0.01) while DNA ploidy status did not show an independent prognostic value. It is concluded that DNA ploidy status is associated with pathological features of aggressive malignancy, but it does not have a determinant role in predicting survival.

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Year:  1990        PMID： 2286806     DOI： 10.1007/bf00303281

Source DB:  PubMed          Journal:  Int J Colorectal Dis        ISSN： 0179-1958            Impact factor:   2.571


  13 in total

Review 1.  Flow cytometry using paraffin-embedded tissue: five years on.

Authors:  D W Hedley
Journal:  Cytometry       Date:  1989-05

2.  Prognostic significance of DNA ploidy in colorectal cancer: a prospective flow cytometric study.

Authors:  D J Jones; M Moore; P F Schofield
Journal:  Br J Surg       Date:  1988-01       Impact factor: 6.939

3.  Prognostic applications of DNA flow cytometry for human solid tumors.

Authors:  O S Frankfurt; S G Arbuck; J L Chin; W R Greco; Z P Pavelic; H K Slocum; A Mittelman; S M Piver; E J Pontes; Y M Rustum
Journal:  Ann N Y Acad Sci       Date:  1986       Impact factor: 5.691

4.  Flow-cytometric demonstration of tumour-cell subpopulations with different DNA content in human colo-rectal carcinoma.

Authors:  S E Petersen; P Bichel; M Lorentzen
Journal:  Eur J Cancer       Date:  1979-04       Impact factor: 9.162

5.  The influence of tumour cell DNA abnormalities on survival in colorectal cancer.

Authors:  N C Armitage; R A Robins; D F Evans; D R Turner; R W Baldwin; J D Hardcastle
Journal:  Br J Surg       Date:  1985-10       Impact factor: 6.939

6.  The relative prognostic value of flow cytometric DNA analysis and conventional clinicopathologic criteria in patients with operable rectal carcinoma.

Authors:  N A Scott; L M Rainwater; H S Wieand; L H Weiland; J H Pemberton; R W Beart; M M Lieber
Journal:  Dis Colon Rectum       Date:  1987-07       Impact factor: 4.585

7.  Flow cytometry of colorectal carcinoma with three-year follow-up.

Authors:  M R Melamed; W E Enker; P Banner; A J Janov; G Kessler; Z Darzynkiewicz
Journal:  Dis Colon Rectum       Date:  1986-03       Impact factor: 4.585

8.  Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinomas.

Authors:  P Quirke; M F Dixon; A D Clayden; P Durdey; J E Dyson; N S Williams; C C Bird
Journal:  J Pathol       Date:  1987-04       Impact factor: 7.996

9.  DNA stemline heterogeneity in colorectal cancer.

Authors:  W Hiddemann; D B Von Bassewitz; H J Kleinemeier; E Schulte-Brochterbeck; J Hauss; B Lingemann; T Büchner; E Grundmann
Journal:  Cancer       Date:  1986-07-15       Impact factor: 6.860

10.  Should flow cytometric DNA analysis precede definitive surgery for colon carcinoma?

Authors:  B F Banner; J E Tomas-De La Vega; D L Roseman; J S Coon
Journal:  Ann Surg       Date:  1985-12       Impact factor: 12.969
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  3 in total

Review 1.  Stage-specific frequency and prognostic significance of aneuploidy in patients with sporadic colorectal cancer--a meta-analysis and current overview.

Authors:  Tilman Laubert; Sandra Freitag-Wolf; Michael Linnebacher; Alexandra König; Brigitte Vollmar; Jens K Habermann
Journal:  Int J Colorectal Dis       Date:  2015-06-09       Impact factor: 2.571

2.  [Comparison of DNA analysis with histomorphologic parameters in stomach cancer].

Authors:  T Böttger; H Gabbert; M Stöckle; S Wellek; H Menke; H C Jauckus; A Grenz; A Heintz; T Junginger
Journal:  Langenbecks Arch Chir       Date:  1992

3.  DNA densitometry of colorectal cancer.

Authors:  G T Deans; K Williamson; P Hamilton; M Heatley; K Arthurs; C C Patterson; B J Rowlands; T G Parks; R A Spence
Journal:  Gut       Date:  1993-11       Impact factor: 23.059
  3 in total

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