Literature DB >> 22848077

High incidence of implantable cardioverter defibrillator malfunctions during radiation therapy: neutrons as a probable cause of soft errors.

Jan Elders1, Martina Kunze-Busch, Robert Jan Smeenk, Joep L R M Smeets.   

Abstract

AIMS: To investigate the behaviour of the implantable cardioverter defibrillator (ICD) function during actual radiotherapy sessions. METHODS AND
RESULTS: Fifteen patients with an ICD underwent 17 radiation treatments for cancer [cumulative dose to the tumour was between 16 Gray (Gy) and 70 Gy; photon beams with maximum energies between 6 megaelectronvolt (MeV) and 18 MeV were employed]. During every session, the ICD was programmed to a monitoring mode to prevent inappropriate therapy delivery. Afterwards, the ICDs were interrogated to ensure proper function. Calculated radiation dose at the ICD site was <1 Gy in all patients. In 5 out of 17 radiation treatments (29%) the ICDs showed 6 malfunctions (35%). We noticed four disturbances in the memory data or device resets during radiation treatment and one case of inappropriate ventricular fibrillation detection due to external noise. In one case a late device data error was observed. All malfunctions occurred at 10 and 18 MeV beam energies.
CONCLUSION: Despite the fact that all recommended precautions were taken to minimize the damage to the ICDs during radiotherapy and the calculated dose to the ICDs was <1 Gy, in 29% of the treatments a malfunction occurred. We observed a possible correlation between the beam energy and the malfunctions. This correlation may be due to an interaction between neutrons produced in the head of the linear accelerator at beam energies ≥10 MeV, and boron-10 which is present in the integrated circuit.

Entities:  

Mesh:

Year:  2012        PMID: 22848077     DOI: 10.1093/europace/eus197

Source DB:  PubMed          Journal:  Europace        ISSN: 1099-5129            Impact factor:   5.214


  16 in total

1.  Radiation tolerance of contemporary implantable cardioverter-defibrillators.

Authors:  Michael Mollerus; Leslee Naslund; Margaret Lipinski; Anne Meyer; Bruce Libey; Ken Dornfeld
Journal:  J Interv Card Electrophysiol       Date:  2013-12-07       Impact factor: 1.900

Review 2.  Arrhythmias and Other Electrophysiology Issues in Cancer Patients Receiving Chemotherapy or Radiation.

Authors:  Federico Viganego; Robin Singh; Michael G Fradley
Journal:  Curr Cardiol Rep       Date:  2016-06       Impact factor: 2.931

3.  Radiotherapy-induced malfunctions of cardiac implantable electronic devices in cancer patients.

Authors:  Vincenzo L Malavasi; Giuseppina De Marco; Jacopo F Imberti; Filippo Placentino; Marco Vitolo; Ercole Mazzeo; Gianfranco Cicoria; Edoardo Casali; Vincenzo Turco; Frank Lohr; Giuseppe Boriani
Journal:  Intern Emerg Med       Date:  2019-12-02       Impact factor: 3.397

4.  Effect of X-ray dose rates higher than 8 Gy/min on the functioning of cardiac implantable electronic devices.

Authors:  Kazuhiko Nakamura; Takahiro Aoyama; Naoki Kaneda; Masashi Otsuji; Yoshitaka Minami; Ami Sakuragi; Masaru Nakamura
Journal:  J Radiat Res       Date:  2020-05-22       Impact factor: 2.724

5.  Malfunctions of implantable cardiac devices in patients receiving proton beam therapy: incidence and predictors.

Authors:  Daniel R Gomez; Falk Poenisch; Chelsea C Pinnix; Tommy Sheu; Joe Y Chang; Nada Memon; Radhe Mohan; Marc A Rozner; Anne H Dougherty
Journal:  Int J Radiat Oncol Biol Phys       Date:  2013-11-01       Impact factor: 7.038

6.  Radiotherapy in patients with cardiac implantable electronic devices: clinical and dosimetric aspects.

Authors:  Giulia Riva; Ombretta Alessandro; Ruggero Spoto; Annamaria Ferrari; Cristina Garibaldi; Federica Cattani; Rosa Luraschi; Elena Rondi; Nicola Colombo; Fulvio Lorenzo Francesco Giovenzana; Carlo Maria Cipolla; Mikolaj Winnicki; Martina Persiani; Fabiana Castelluccia; Massimo Sarra Fiore; Roberto Orecchia; Barbara Alicja Jereczek-Fossa
Journal:  Med Oncol       Date:  2018-04-17       Impact factor: 3.064

7.  DEGRO/DGK guideline for radiotherapy in patients with cardiac implantable electronic devices.

Authors:  Benjamin Gauter-Fleckenstein; Carsten W Israel; Marc Dorenkamp; Jürgen Dunst; Mattias Roser; Rainer Schimpf; Volker Steil; Jörg Schäfer; Ulrike Höller; Frederik Wenz
Journal:  Strahlenther Onkol       Date:  2015-03-05       Impact factor: 3.621

8.  Radiotherapy of patients with cardiac implantable electronic devices according to the DEGRO/DGK guideline-is the risk of relevant errors overestimated?

Authors:  Felix Steger; Matthias G Hautmann; Christoph Süß; Ute Hubauer; Ekrem Ücer; Lars Maier; Oliver Kölbl; Carsten Jungbauer
Journal:  Strahlenther Onkol       Date:  2019-08-09       Impact factor: 3.621

9.  A clinical example of extreme dose exposure for an implanted cardioverter-defibrillator : Beyond the DEGRO guidelines.

Authors:  Yoana Hristova; Janett Köhn; Stefanie Preuß; Claus Rödel; Panagiotis Balermpas
Journal:  Strahlenther Onkol       Date:  2017-05-31       Impact factor: 3.621

Review 10.  Management of radiation therapy patients with cardiac defibrillator or pacemaker.

Authors:  Francesca Salerno; Sara Gomellini; Cristina Caruso; Raffaele Barbara; Daniela Musio; Tamara Coppi; Mario Cardinale; Vincenzo Tombolini; Ugo de Paula
Journal:  Radiol Med       Date:  2015-12-26       Impact factor: 3.469

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