Literature DB >> 22837515

Molecular biology. Use and abuse of RNAi to study mammalian gene function.

William G Kaelin1.   

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Year:  2012        PMID： 22837515      PMCID： PMC3705935          DOI： 10.1126/science.1225787

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


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  15 in total

1.  A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.

Authors:  Guangchao Sui; Christina Soohoo; El Bachir Affar; Frédérique Gay; Yujiang Shi; William C Forrester; Yang Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

2.  Drug development: Raise standards for preclinical cancer research.

Authors:  C Glenn Begley; Lee M Ellis
Journal:  Nature       Date:  2012-03-28       Impact factor: 49.962

3.  Minimizing the risk of reporting false positives in large-scale RNAi screens.

Authors:  Christophe J Echeverri; Philip A Beachy; Buzz Baum; Michael Boutros; Frank Buchholz; Sumit K Chanda; Julian Downward; Jan Ellenberg; Andrew G Fraser; Nir Hacohen; William C Hahn; Aimee L Jackson; Amy Kiger; Peter S Linsley; Lawrence Lum; Yong Ma; Bernard Mathey-Prévôt; David E Root; David M Sabatini; Jussi Taipale; Norbert Perrimon; René Bernards
Journal:  Nat Methods       Date:  2006-10       Impact factor: 28.547

4.  Factors affecting reproducibility between genome-scale siRNA-based screens.

Authors:  Nicholas J Barrows; Caroline Le Sommer; Mariano A Garcia-Blanco; James L Pearson
Journal:  J Biomol Screen       Date:  2010-07-12

5.  A system for stable expression of short interfering RNAs in mammalian cells.

Authors:  Thijn R Brummelkamp; René Bernards; Reuven Agami
Journal:  Science       Date:  2002-03-21       Impact factor: 47.728

6.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.

Authors:  S M Elbashir; J Harborth; W Lendeckel; A Yalcin; K Weber; T Tuschl
Journal:  Nature       Date:  2001-05-24       Impact factor: 49.962

7.  RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells.

Authors:  Ralf Kittler; Laurence Pelletier; Chunling Ma; Ina Poser; Steffi Fischer; Anthony A Hyman; Frank Buchholz
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-03       Impact factor: 11.205

Review 8.  Knockdown screens to knockout HIV-1.

Authors:  Stephen P Goff
Journal:  Cell       Date:  2008-10-31       Impact factor: 41.582

9.  A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

Authors:  Ji Luo; Michael J Emanuele; Danan Li; Chad J Creighton; Michael R Schlabach; Thomas F Westbrook; Kwok-Kin Wong; Stephen J Elledge
Journal:  Cell       Date:  2009-05-29       Impact factor: 41.582

10.  Haploid genetic screens in human cells identify host factors used by pathogens.

Authors:  Jan E Carette; Carla P Guimaraes; Malini Varadarajan; Annie S Park; Irene Wuethrich; Alzbeta Godarova; Maciej Kotecki; Brent H Cochran; Eric Spooner; Hidde L Ploegh; Thijn R Brummelkamp
Journal:  Science       Date:  2009-11-27       Impact factor: 63.714
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  89 in total

1.  ScreenBEAM: a novel meta-analysis algorithm for functional genomics screens via Bayesian hierarchical modeling.

Authors:  Jiyang Yu; Jose Silva; Andrea Califano
Journal:  Bioinformatics       Date:  2015-09-28       Impact factor: 6.937

Review 2.  Functional genomics to uncover drug mechanism of action.

Authors:  Sebastian M B Nijman
Journal:  Nat Chem Biol       Date:  2015-11-17       Impact factor: 15.040

3.  SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.

Authors:  Michael W McBurney; Katherine V Clark-Knowles; Annabelle Z Caron; Douglas A Gray
Journal:  Genes Cancer       Date:  2013-03

Review 4.  Transcriptional and Epigenomic Regulation of Adipogenesis.

Authors:  Ji-Eun Lee; Hannah Schmidt; Binbin Lai; Kai Ge
Journal:  Mol Cell Biol       Date:  2019-05-14       Impact factor: 4.272

Review 5.  Proximal nephron.

Authors:  Jia L Zhuo; Xiao C Li
Journal:  Compr Physiol       Date:  2013-07       Impact factor: 9.090

6.  CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.

Authors:  Ruilin Tian; Mariam A Gachechiladze; Connor H Ludwig; Matthew T Laurie; Jason Y Hong; Diane Nathaniel; Anika V Prabhu; Michael S Fernandopulle; Rajan Patel; Mehrnoosh Abshari; Michael E Ward; Martin Kampmann
Journal:  Neuron       Date:  2019-08-15       Impact factor: 17.173

Review 7.  Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9.

Authors:  Hua Shen; Cliona M McHale; Martyn T Smith; Luoping Zhang
Journal:  Mutat Res Rev Mutat Res       Date:  2015-01-25       Impact factor: 5.657

8.  Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions.

Authors:  Christopher J Lord; Niall Quinn; Colm J Ryan
Journal:  Elife       Date:  2020-05-28       Impact factor: 8.140

9.  Comparative analysis of RNAi screening technologies at genome-scale reveals an inherent processing inefficiency of the plasmid-based shRNA hairpin.

Authors:  Bhavneet Bhinder; David Shum; Hakim Djaballah
Journal:  Comb Chem High Throughput Screen       Date:  2014-02       Impact factor: 1.339

Review 10.  Hunting Viral Receptors Using Haploid Cells.

Authors:  Sirika Pillay; Jan E Carette
Journal:  Annu Rev Virol       Date:  2015-07-02       Impact factor: 10.431
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