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Literature DB >> 22811528

Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.

Chunye Lu¹, Zeping Luo, Stefanie Jäger, Nevan J Krogan, B Matija Peterlin.

Abstract

Moloney leukemia virus type 10 protein (MOV10) is an RNA helicase that is induced by type I interferon. It inhibits HIV replication at several steps of its replicative cycle. Of interest, MOV10 is a component of mRNA processing (P) bodies, which inhibit retrotransposition (RTP) of intracisternal A particles (IAP). In this report, we studied the effects of MOV10 on IAP RTP and its dependence on P bodies. Indeed, MOV10 inhibited IAP RTP. It decreased significantly not only the products of reverse transcriptase but also its endogenous activity. MOV10 also associated with IAP RNA. Furthermore, although it was found in IAP virus-like particles, it did not affect their incorporation of IAP RNA, primer tRNAPhe (phenylalanine tRNA), or IAP Gag. Concerning P bodies, the exogenously expressed MOV10 had no effect on their size and number, and the inhibition of IAP RTP persisted despite the depletion of their RCK subunit. Thus, by interfering with reverse transcription, MOV10 inhibits IAP RTP, and this inhibition is independent of P bodies.

Entities: Disease Gene

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Year: 2012 PMID： 22811528 PMCID： PMC3457264 DOI： 10.1128/JVI.00868-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

19 in total

Review 1. SF1 and SF2 helicases: family matters.

Authors: Margaret E Fairman-Williams; Ulf-Peter Guenther; Eckhard Jankowsky
Journal: Curr Opin Struct Biol Date: 2010-04-22 Impact factor: 6.809

2. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.

Authors: Leonie Unterholzner; Elisa Izaurralde
Journal: Mol Cell Date: 2004-11-19 Impact factor: 17.970

3. Synthesis and turnover of intracisternal A-particle structural protein in cultured neuroblastoma cells.

Authors: K K Lueders; E L Kuff
Journal: J Biol Chem Date: 1975-07-10 Impact factor: 5.157

4. Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.

Authors: Xiaojun Wang; Yanxing Han; Ying Dang; William Fu; Tao Zhou; Roger G Ptak; Yong-Hui Zheng
Journal: J Biol Chem Date: 2010-03-09 Impact factor: 5.157

5. Detection of a human intracisternal A-type retroviral particle antigenically related to HIV.

Authors: R F Garry; C D Fermin; D J Hart; S S Alexander; L A Donehower; H Luo-Zhang
Journal: Science Date: 1990-11-23 Impact factor: 47.728

6. Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity.

Authors: Vyacheslav Furtak; Alok Mulky; Stephen A Rawlings; Lina Kozhaya; KyeongEun Lee; Vineet N Kewalramani; Derya Unutmaz
Journal: PLoS One Date: 2010-02-05 Impact factor: 3.240

7. Detection of a human intracisternal retroviral particle associated with CD4+ T-cell deficiency.

Authors: S Gupta; C E Ribak; S Gollapudi; C H Kim; S Z Salahuddin
Journal: Proc Natl Acad Sci U S A Date: 1992-08-15 Impact factor: 11.205

8. Long terminal repeat sequences of intracisternal A particle genes in the Syrian hamster genome: identification of tRNAPhe as a putative primer tRNA.

Authors: M Ono; H Ohishi
Journal: Nucleic Acids Res Date: 1983-10-25 Impact factor: 16.971

9. HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells.

Authors: Metka Lenassi; Gerard Cagney; Maofu Liao; Tomaz Vaupotic; Koen Bartholomeeusen; Yifan Cheng; Nevan J Krogan; Ana Plemenitas; B Matija Peterlin
Journal: Traffic Date: 2010-01 Impact factor: 6.215

10. Nucleotide sequence of a complete mouse intracisternal A-particle genome: relationship to known aspects of particle assembly and function.

Authors: J A Mietz; Z Grossman; K K Lueders; E L Kuff
Journal: J Virol Date: 1987-10 Impact factor: 6.549

21 in total

Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.

Review 1. SF1 and SF2 helicases: family matters.

2. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.

3. Synthesis and turnover of intracisternal A-particle structural protein in cultured neuroblastoma cells.

4. Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.

5. Detection of a human intracisternal A-type retroviral particle antigenically related to HIV.

6. Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity.

7. Detection of a human intracisternal retroviral particle associated with CD4+ T-cell deficiency.

8. Long terminal repeat sequences of intracisternal A particle genes in the Syrian hamster genome: identification of tRNAPhe as a putative primer tRNA.

9. HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells.

10. Nucleotide sequence of a complete mouse intracisternal A-particle genome: relationship to known aspects of particle assembly and function.

1. The MOV10 helicase inhibits LINE-1 mobility.

2. Hili Inhibits HIV Replication in Activated T Cells.

3. Effect of P-body component Mov10 on HCV virus production and infectivity.

4. The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.

5. Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.

6. Cytoplasmic RNA Granules and Viral Infection.

7. Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity.

8. UPF1 is crucial for the infectivity of human immunodeficiency virus type 1 progeny virions.

Review 9. From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication.

10. CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.