Literature DB >> 22789542

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

Katharina Schlacher1, Hong Wu, Maria Jasin.   

Abstract

Genes mutated in patients with Fanconi anemia (FA) interact with the DNA repair genes BRCA1 and BRCA2/FANCD1 to suppress tumorigenesis, but the molecular functions ascribed to them cannot fully explain all of their cellular roles. Here, we show a repair-independent requirement for FA genes, including FANCD2, and BRCA1 in protecting stalled replication forks from degradation. Fork protection is surprisingly rescued in FANCD2-deficient cells by elevated RAD51 levels or stabilized RAD51 filaments. Moreover, FANCD2-mediated fork protection is epistatic with RAD51 functions, revealing an unanticipated fork protection pathway that connects FA genes to RAD51 and the BRCA1/2 breast cancer suppressors. Collective results imply a unified molecular mechanism for repair-independent functions of FA, RAD51, and BRCA1/2 proteins in preventing genomic instability and suppressing tumorigenesis.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22789542      PMCID： PMC3954744          DOI： 10.1016/j.ccr.2012.05.015

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  45 in total

1.  Positional cloning of a novel Fanconi anemia gene, FANCD2.

Authors:  C Timmers; T Taniguchi; J Hejna; C Reifsteck; L Lucas; D Bruun; M Thayer; B Cox; S Olson; A D D'Andrea; R Moses; M Grompe
Journal:  Mol Cell       Date:  2001-02       Impact factor: 17.970

2.  A touching moment for Smc5/6: from ssDNA binding to repair.

Authors:  Patrice Y Ohouo; Marcus B Smolka
Journal:  Cell Cycle       Date:  2011-04-15       Impact factor: 4.534

3.  Mechanism of RAD51-dependent DNA interstrand cross-link repair.

Authors:  David T Long; Markus Räschle; Vladimir Joukov; Johannes C Walter
Journal:  Science       Date:  2011-07-01       Impact factor: 47.728

4.  Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.

Authors:  Frédéric Langevin; Gerry P Crossan; Ivan V Rosado; Mark J Arends; Ketan J Patel
Journal:  Nature       Date:  2011-07-06       Impact factor: 49.962

5.  Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

Authors:  Katharina Schlacher; Nicole Christ; Nicolas Siaud; Akinori Egashira; Hong Wu; Maria Jasin
Journal:  Cell       Date:  2011-05-13       Impact factor: 41.582

6.  Brca1 controls homology-directed DNA repair.

Authors:  M E Moynahan; J W Chiu; B H Koller; M Jasin
Journal:  Mol Cell       Date:  1999-10       Impact factor: 17.970

7.  Nucleotide deficiency promotes genomic instability in early stages of cancer development.

Authors:  Assaf C Bester; Maayan Roniger; Yifat S Oren; Michael M Im; Dan Sarni; Malka Chaoat; Aaron Bensimon; Gideon Zamir; Donna S Shewach; Batsheva Kerem
Journal:  Cell       Date:  2011-04-29       Impact factor: 41.582

Review 8.  FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair.

Authors:  Kelly E Cybulski; Niall G Howlett
Journal:  Cell Cycle       Date:  2011-06-01       Impact factor: 4.534

9.  Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

Authors:  Ivan V Rosado; Frédéric Langevin; Gerry P Crossan; Minoru Takata; Ketan J Patel
Journal:  Nat Struct Mol Biol       Date:  2011-11-13       Impact factor: 15.369

10.  Regulation of Rev1 by the Fanconi anemia core complex.

Authors:  Hyungjin Kim; Kailin Yang; Donniphat Dejsuphong; Alan D D'Andrea
Journal:  Nat Struct Mol Biol       Date:  2012-01-22       Impact factor: 15.369
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  459 in total

Review 1.  A tough row to hoe: when replication forks encounter DNA damage.

Authors:  Darshil R Patel; Robert S Weiss
Journal:  Biochem Soc Trans       Date:  2018-12-04       Impact factor: 5.407

2.  High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.

Authors:  Ann Christin Parplys; Jasna Irena Seelbach; Saskia Becker; Matthias Behr; Agnieszka Wrona; Camilla Jend; Wael Yassin Mansour; Simon Andreas Joosse; Horst-Werner Stuerzbecher; Helmut Pospiech; Cordula Petersen; Ekkehard Dikomey; Kerstin Borgmann
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

3.  Natural history and management of Fanconi anemia patients with head and neck cancer: A 10-year follow-up.

Authors:  David I Kutler; Krupa R Patel; Arleen D Auerbach; Jennifer Kennedy; Francis P Lach; Erica Sanborn; Marc A Cohen; William I Kuhel; Agata Smogorzewska
Journal:  Laryngoscope       Date:  2015-10-20       Impact factor: 3.325

4.  Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.

Authors:  María Belén Vallerga; Sabrina F Mansilla; María Belén Federico; Agustina P Bertolin; Vanesa Gottifredi
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-16       Impact factor: 11.205

5.  SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.

Authors:  Yusuke Okamoto; Masako Abe; Anfeng Mu; Yasuko Tempaku; Colette B Rogers; Ayako L Mochizuki; Yoko Katsuki; Masato T Kanemaki; Akifumi Takaori-Kondo; Alexandra Sobeck; Anja-Katrin Bielinsky; Minoru Takata
Journal:  Blood       Date:  2021-01-21       Impact factor: 22.113

Review 6.  Functional assays for analysis of variants of uncertain significance in BRCA2.

Authors:  Lucia Guidugli; Aura Carreira; Sandrine M Caputo; Asa Ehlen; Alvaro Galli; Alvaro N A Monteiro; Susan L Neuhausen; Thomas V O Hansen; Fergus J Couch; Maaike P G Vreeswijk
Journal:  Hum Mutat       Date:  2013-12-03       Impact factor: 4.878

Review 7.  Fanconi anaemia and the repair of Watson and Crick DNA crosslinks.

Authors:  Molly C Kottemann; Agata Smogorzewska
Journal:  Nature       Date:  2013-01-17       Impact factor: 49.962

8.  Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection.

Authors:  Shan Li; Zeno Lavagnino; Delphine Lemacon; Lingzhen Kong; Alessandro Ustione; Xuewen Ng; Yuanya Zhang; Yingchun Wang; Bin Zheng; Helen Piwnica-Worms; Alessandro Vindigni; David W Piston; Zhongsheng You
Journal:  Mol Cell       Date:  2019-04-30       Impact factor: 17.970

9.  CtIP mediates replication fork recovery in a FANCD2-regulated manner.

Authors:  Jung Eun Yeo; Eu Han Lee; Eric A Hendrickson; Alexandra Sobeck
Journal:  Hum Mol Genet       Date:  2014-02-20       Impact factor: 6.150

Review 10.  What is wrong with Fanconi anemia cells?

Authors:  Sharon B Cantor; Robert M Brosh
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534
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