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Literature DB >> 21527828

FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair.

Abstract

Fanconi anemia (FA) is a rare genetic disease characterized by congenital abnormalities, bone marrow failure and heightened cancer susceptibility. The FA proteins are known to function in the cellular defense against DNA interstrand crosslinks (ICLs), a process that remains poorly understood. A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C. In this perspective we describe the discovery of FANCP/SLX4 and discuss how these new findings collectively refine our understanding of DNA ICL repair.

Entities: Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 21527828 PMCID： PMC3142459 DOI： 10.4161/cc.10.11.15818

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

76 in total

1. Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.

Authors: Sietske T Bakker; Henri J van de Vrugt; Martin A Rooimans; Anneke B Oostra; Jurgen Steltenpool; Elly Delzenne-Goette; Anja van der Wal; Martin van der Valk; Hans Joenje; Hein te Riele; Johan P de Winter
Journal: Hum Mol Genet Date: 2009-06-26 Impact factor: 6.150

2. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response.

Authors: Min Huang; Jung Min Kim; Bunsyo Shiotani; Kailin Yang; Lee Zou; Alan D D'Andrea
Journal: Mol Cell Date: 2010-07-30 Impact factor: 17.970

Review 3. Mammalian nucleotide excision repair proteins and interstrand crosslink repair.

Authors: Richard D Wood
Journal: Environ Mol Mutagen Date: 2010-07 Impact factor: 3.216

4. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

Authors: Agata Smogorzewska; Rohini Desetty; Takamune T Saito; Michael Schlabach; Francis P Lach; Mathew E Sowa; Alan B Clark; Thomas A Kunkel; J Wade Harper; Monica P Colaiácovo; Stephen J Elledge
Journal: Mol Cell Date: 2010-07-09 Impact factor: 17.970

5. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

Authors: Katja Kratz; Barbara Schöpf; Svenja Kaden; Ataman Sendoel; Ralf Eberhard; Claudio Lademann; Elda Cannavó; Alessandro A Sartori; Michael O Hengartner; Josef Jiricny
Journal: Cell Date: 2010-07-09 Impact factor: 41.582

6. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

Authors: Ivan M Muñoz; Karolina Hain; Anne-Cécile Déclais; Mary Gardiner; Geraldine W Toh; Luis Sanchez-Pulido; Johannes M Heuckmann; Rachel Toth; Thomas Macartney; Berina Eppink; Roland Kanaar; Chris P Ponting; David M J Lilley; John Rouse
Journal: Mol Cell Date: 2009-07-10 Impact factor: 17.970

7. Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.

Authors: Samira Fekairi; Sarah Scaglione; Charly Chahwan; Ewan R Taylor; Agnès Tissier; Stéphane Coulon; Meng-Qiu Dong; Cristian Ruse; John R Yates; Paul Russell; Robert P Fuchs; Clare H McGowan; Pierre-Henri L Gaillard
Journal: Cell Date: 2009-07-10 Impact factor: 41.582

Review 8. The Fanconi anemia protein interaction network: casting a wide net.

Authors: Meghan A Rego; Frederick W Kolling; Niall G Howlett
Journal: Mutat Res Date: 2008-12-03 Impact factor: 2.433

9. Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

Authors: Gerry P Crossan; Louise van der Weyden; Ivan V Rosado; Frederic Langevin; Pierre-Henri L Gaillard; Rebecca E McIntyre; Ferdia Gallagher; Mikko I Kettunen; David Y Lewis; Kevin Brindle; Mark J Arends; David J Adams; Ketan J Patel
Journal: Nat Genet Date: 2011-01-16 Impact factor: 38.330

10. Mutations of the SLX4 gene in Fanconi anemia.

Authors: Yonghwan Kim; Francis P Lach; Rohini Desetty; Helmut Hanenberg; Arleen D Auerbach; Agata Smogorzewska
Journal: Nat Genet Date: 2011-01-16 Impact factor: 38.330

33 in total

Review 1. Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway.

Authors: Hyungjin Kim; Alan D D'Andrea
Journal: Genes Dev Date: 2012-07-01 Impact factor: 11.361

2. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.

Authors: Heike N Pfäffle; Meng Wang; Liliana Gheorghiu; Natalie Ferraiolo; Patricia Greninger; Kerstin Borgmann; Jeffrey Settleman; Cyril H Benes; Lecia V Sequist; Lee Zou; Henning Willers
Journal: Cancer Res Date: 2013-08-21 Impact factor: 12.701

FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair.

1. Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.

2. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response.

Review 3. Mammalian nucleotide excision repair proteins and interstrand crosslink repair.

4. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

5. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

6. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

7. Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.

Review 8. The Fanconi anemia protein interaction network: casting a wide net.

9. Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

10. Mutations of the SLX4 gene in Fanconi anemia.

Review 1. Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway.

2. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.

3. Regulation of the Fanconi anemia pathway by a SUMO-like delivery network.

Review 4. The Fanconi anemia ID2 complex: dueling saxes at the crossroads.

5. Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.

6. Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response.

7. From arrest to escape: HIV-1 Vpr cuts a deal.

8. Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma.

Review 9. REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.

10. Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING.