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Literature DB >> 22743709

Ubiquitin removal in the TGF-β pathway.

Abstract

The transforming growth factor (TGF-β) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-β type I receptor. Both ubiquitin-specific peptidase-4 (USP4) and -15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action.

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Year: 2012 PMID： 22743709 DOI： 10.1038/ncb2534

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

11 in total

1. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.

Authors: P Kavsak; R K Rasmussen; C G Causing; S Bonni; H Zhu; G H Thomsen; J L Wrana
Journal: Mol Cell Date: 2000-12 Impact factor: 17.970

Review 2. Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Authors: Yigong Shi; Joan Massagué
Journal: Cell Date: 2003-06-13 Impact factor: 41.582

3. Will the ubiquitin system furnish as many drug targets as protein kinases?

Authors: Philip Cohen; Marianna Tcherpakov
Journal: Cell Date: 2010-11-24 Impact factor: 41.582

4. USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma.

Authors: Pieter J A Eichhorn; Laura Rodón; Alba Gonzàlez-Juncà; Annette Dirac; Magüi Gili; Elena Martínez-Sáez; Claudia Aura; Ignasi Barba; Vicente Peg; Aleix Prat; Isabel Cuartas; Jose Jimenez; David García-Dorado; Juan Sahuquillo; Réné Bernards; José Baselga; Joan Seoane
Journal: Nat Med Date: 2012-02-19 Impact factor: 53.440

5. USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.

Authors: Long Zhang; FangFang Zhou; Yvette Drabsch; Rui Gao; B Ewa Snaar-Jagalska; Craig Mickanin; Huizhe Huang; Kelly-Ann Sheppard; Jeff A Porter; Chris X Lu; Peter ten Dijke
Journal: Nat Cell Biol Date: 2012-06-17 Impact factor: 28.824

6. A poised chromatin platform for TGF-β access to master regulators.

Authors: Qiaoran Xi; Zhanxin Wang; Alexia-Ileana Zaromytidou; Xiang H-F Zhang; Lai-Fong Chow-Tsang; Jing X Liu; Hyesoo Kim; Afsar Barlas; Katia Manova-Todorova; Vesa Kaartinen; Lorenz Studer; Willie Mark; Dinshaw J Patel; Joan Massagué
Journal: Cell Date: 2011-12-23 Impact factor: 41.582

Review 7. TGFbeta in Cancer.

Authors: Joan Massagué
Journal: Cell Date: 2008-07-25 Impact factor: 41.582

8. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.

Authors: Claudio Alarcón; Alexia-Ileana Zaromytidou; Qiaoran Xi; Sheng Gao; Jianzhong Yu; Sho Fujisawa; Afsar Barlas; Alexandria N Miller; Katia Manova-Todorova; Maria J Macias; Gopal Sapkota; Duojia Pan; Joan Massagué
Journal: Cell Date: 2009-11-13 Impact factor: 41.582

9. USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

Authors: Masafumi Inui; Andrea Manfrin; Anant Mamidi; Graziano Martello; Leonardo Morsut; Sandra Soligo; Elena Enzo; Stefano Moro; Simona Polo; Sirio Dupont; Michelangelo Cordenonsi; Stefano Piccolo
Journal: Nat Cell Biol Date: 2011-09-25 Impact factor: 28.824

Review 10. Phosphatases in SMAD regulation.

Authors: David L Bruce; Gopal P Sapkota
Journal: FEBS Lett Date: 2012-02-11 Impact factor: 4.124

23 in total

1. PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells.

Authors: Yueli Shi; Xinyu Wang; Zhiyong Xu; Ying He; Chunyi Guo; Lingjuan He; Caijuan Huan; Changhong Cai; Jiaqi Huang; Jie Zhang; Yiqing Li; Chunlai Zeng; Xue Zhang; Linrun Wang; Yuehai Ke; Hongqiang Cheng
Journal: J Biol Chem Date: 2020-07-31 Impact factor: 5.157

2. USP11 Enhances TGFβ-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis.

Authors: Daniel A Garcia; Christina Baek; M Valeria Estrada; Tiffani Tysl; Eric J Bennett; Jing Yang; John T Chang
Journal: Mol Cancer Res Date: 2018-05-03 Impact factor: 5.852

3. Expression of USP15, TβR-I and Smad7 in psoriasis.

Authors: Ai-Ping Feng; Yi-Min He; Xin-Xin Liu; Jia-Wen Li; Ya-Ting Tu; Feng Hu; Shan-Juan Chen
Journal: J Huazhong Univ Sci Technolog Med Sci Date: 2014-06-18

4. Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation.

Authors: Dohun Pyeon; Khalid Amine Timani; Fahad Gulraiz; Johnny J He; In-Woo Park
Journal: Virus Res Date: 2016-07-25 Impact factor: 3.303

Review 5. Transforming growth factor-beta and its implication in the malignancy of gliomas.

Authors: Laurent-Olivier Roy; Marie-Belle Poirier; David Fortin
Journal: Target Oncol Date: 2014-03-05 Impact factor: 4.493

6. AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4.

Authors: Li Xiao; Xiang Peng; Fuyou Liu; Chengyuan Tang; Chun Hu; Xiaoxuan Xu; Ming Wang; Ying Luo; Shikun Yang; Panai Song; Ping Xiao; Yashpal S Kanwar; Lin Sun
Journal: BMC Cell Biol Date: 2015-03-06 Impact factor: 4.241

7. Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia.

Authors: Jingping Ge; Marisa Apicella; Jason A Mills; Loïc Garçon; Deborah L French; Mitchell J Weiss; Monica Bessler; Philip J Mason
Journal: PLoS One Date: 2015-08-10 Impact factor: 3.240

Review 8. USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.

Authors: Iraia García-Santisteban; Godefridus J Peters; Elisa Giovannetti; Jose Antonio Rodríguez
Journal: Mol Cancer Date: 2013-08-10 Impact factor: 27.401

9. microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression.

Authors: Mi Jeong Heo; Young Mi Kim; Ja Hyun Koo; Yoon Mee Yang; Jihyun An; Sook-Kyung Lee; Seung Jin Lee; Kang Mo Kim; Joong-Won Park; Sang Geon Kim
Journal: Oncotarget Date: 2014-05-15

Review 10. Deubiquitylating enzymes and DNA damage response pathways.

Authors: Xavier Jacq; Mark Kemp; Niall M B Martin; Stephen P Jackson
Journal: Cell Biochem Biophys Date: 2013-09 Impact factor: 2.194