A Ackermann1, L E Pillunat. 1. Augenklinik des Universitätsklinikums Erlangen, Erlangen, Deutschland. A_Ackermann@hotmail.com
Abstract
BACKGROUND: This study was carried out to test the reliability of a defined cut-off value for retinal thickness with estimation of the sensitivity, specificity and formation of an edema index in comparison to retinal thickness. MATERIALS AND METHODS: This was a single center prospective clinical non-blinded study of 100 eyes, including 22 eyes with central vein or branch vein occlusions, 20 eyes with diabetic macular edema, 6 eyes with postoperative macular edema, 2 eyes with uveitis and 50 healthy eyes. Detection of macular edema was carried out by third generation optical coherence tomography. Using the latest version of the Heidelberg retina tomograph (HRT 3) series of five images were produced and evaluated. The 9-zone circle of the HRT was used as the analysis contour. RESULTS: The reliability of measuring retinal thickness with the HRT in the subjects showed an intraclass correlation between 0.248 and 0.740 and patients with macular edema showed values between 0.515 and 0.949. The reliability of the edema index with the HRT in the subjects showed an intraclass correlation between 0.461 and 0.826 and patients with macular edema showed values between 0.383 and 0.826. The calculated cut-off values were between 285 µm and 360 µm. The corresponding sensitivity values were between 74.7% and 95.9% with a corresponding specificity of 74.7-90.2%. There was also a highly significant correlation between the edema index and retinal thickness (p < 0.001). CONCLUSIONS: The retina module of the latest generation HRT is capable of reproducible measurement of the retinal thickness in micrometers. The defined cut-off values correspond to expectations and can be used in this form in the clinical practice.
BACKGROUND: This study was carried out to test the reliability of a defined cut-off value for retinal thickness with estimation of the sensitivity, specificity and formation of an edema index in comparison to retinal thickness. MATERIALS AND METHODS: This was a single center prospective clinical non-blinded study of 100 eyes, including 22 eyes with central vein or branch vein occlusions, 20 eyes with diabetic macular edema, 6 eyes with postoperative macular edema, 2 eyes with uveitis and 50 healthy eyes. Detection of macular edema was carried out by third generation optical coherence tomography. Using the latest version of the Heidelberg retina tomograph (HRT 3) series of five images were produced and evaluated. The 9-zone circle of the HRT was used as the analysis contour. RESULTS: The reliability of measuring retinal thickness with the HRT in the subjects showed an intraclass correlation between 0.248 and 0.740 and patients with macular edema showed values between 0.515 and 0.949. The reliability of the edema index with the HRT in the subjects showed an intraclass correlation between 0.461 and 0.826 and patients with macular edema showed values between 0.383 and 0.826. The calculated cut-off values were between 285 µm and 360 µm. The corresponding sensitivity values were between 74.7% and 95.9% with a corresponding specificity of 74.7-90.2%. There was also a highly significant correlation between the edema index and retinal thickness (p < 0.001). CONCLUSIONS: The retina module of the latest generation HRT is capable of reproducible measurement of the retinal thickness in micrometers. The defined cut-off values correspond to expectations and can be used in this form in the clinical practice.
Authors: Mila Kisilevsky; Christopher Hudson; John G Flanagan; Ravi Krishna Nrusimhadevara; Kit Guan; Tien Wong; Mark Mandelcorn; Wai-Ching Lam; Robert G Devenyi Journal: Arch Ophthalmol Date: 2006-03