Literature DB >> 22733615

AFB(1) -induced mutagenesis of the gpt gene in AS52 cells.

Roongtiwa Wattanawaraporn1, Min Young Kim, Jillian Adams, Laura J Trudel, Leslie L Woo, Robert G Croy, John M Essigmann, Gerald N Wogan.   

Abstract

Aflatoxin B(1) (AFB(1) ) is a potent mutagen and an important risk factor for hepatocellular carcinoma (HCC) in humans. Transgenic mouse strains and cells in culture have been used to detect different types of mutations caused by AFB(1) and investigate the molecular determinants of their location and frequency. The AFB(1) mutational spectrum in the gpt gene was markedly different in AS52 cells compared with the liver in gpt delta B6C3F1 transgenic mice. The results demonstrate the importance of metabolism, chromosomal location, transcription and selection conditions on mutational spectra.
Copyright © 2012 Wiley Periodicals, Inc.

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Year:  2012        PMID： 22733615      PMCID： PMC3897198          DOI： 10.1002/em.21711

Source DB:  PubMed          Journal:  Environ Mol Mutagen        ISSN： 0893-6692            Impact factor:   3.216


  40 in total

Review 1.  Treatment and sampling protocols for transgenic mutation assays.

Authors:  John A Heddle; Hans-Joerg Martus; George R Douglas
Journal:  Environ Mol Mutagen       Date:  2003       Impact factor: 3.216

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Journal:  Mutat Res       Date:  1986-04       Impact factor: 2.433

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Authors:  K R Tindall; L F Stankowski; R Machanoff; A W Hsie
Journal:  Mol Cell Biol       Date:  1984-07       Impact factor: 4.272

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Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

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Authors:  P L Foster; E Eisenstadt; J H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

8.  Phenotypic lag and mutation to 6-thioguanine resistance in diploid human lymphoblasts.

Authors:  W G Thilly; J G Deluca; H Hoppe; B W Penman
Journal:  Mutat Res       Date:  1978-04       Impact factor: 2.433

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Authors:  S A Leadon; M E Zolan; P C Hanawalt
Journal:  Nucleic Acids Res       Date:  1983-08-25       Impact factor: 16.971

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Authors:  L F Stankowski; K R Tindall; A W Hsie
Journal:  Mutat Res       Date:  1986-04       Impact factor: 2.433
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  2 in total

1.  An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity.

Authors:  Preechaya Tajai; Bogdan I Fedeles; Tawit Suriyo; Panida Navasumrit; Jantamas Kanitwithayanun; John M Essigmann; Jutamaad Satayavivad
Journal:  Free Radic Biol Med       Date:  2017-12-28       Impact factor: 7.376

2.  AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249.

Authors:  Mao-Wen Weng; Hyun-Wook Lee; Bongkun Choi; Hsiang-Tsui Wang; Yu Hu; Manju Mehta; Dhimant Desai; Shantu Amin; Yi Zheng; Moon-Shong Tang
Journal:  Oncotarget       Date:  2017-03-14
  2 in total

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