Literature DB >> 347279

Phenotypic lag and mutation to 6-thioguanine resistance in diploid human lymphoblasts.

W G Thilly, J G Deluca, H Hoppe, B W Penman.   

Abstract

Mutants of a diploid human lymphoblast line resistant to 6-thioguanine (6TG) appear 6--16 generations after treatment with any of a diverse group of mutagents: methylnitrosourea (MNU), methylnitrosoguanidine (MNNG), ICR-191, 5-bromodeoxyuridine (BUdR). A hypothesis is advanced that expression of the 6-thioguanine-resistant state may require the removal of essentially all pre-existing hypoxanthine--guanine phosphoribosyl transferase (HGPRT) molecules via division, dilution, and protein turnover. Design of protocols for quantitative mutation assays requires attention to this phenomenon.

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Year:  1978        PMID： 347279     DOI： 10.1016/0027-5107(78)90068-4

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  6 in total

1.  AFB(1) -induced mutagenesis of the gpt gene in AS52 cells.

Authors:  Roongtiwa Wattanawaraporn; Min Young Kim; Jillian Adams; Laura J Trudel; Leslie L Woo; Robert G Croy; John M Essigmann; Gerald N Wogan
Journal:  Environ Mol Mutagen       Date:  2012-06-26       Impact factor: 3.216

2.  Chemically induced mutagenesis in a shuttle vector with a low-background mutant frequency.

Authors:  N R Drinkwater; D K Klinedinst
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

3.  Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice.

Authors:  Leslie L Woo; Patricia A Egner; Crystal L Belanger; Roongtiwa Wattanawaraporn; Laura J Trudel; Robert G Croy; John D Groopman; John M Essigmann; Gerald N Wogan; Jason T Bouhenguel
Journal:  Toxicol Sci       Date:  2011-04-19       Impact factor: 4.849

4.  T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood.

Authors:  R J Albertini; K L Castle; W R Borcherding
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

5.  Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture.

Authors:  B L Allen-Hoffmann; J G Rheinwald
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

6.  Evidence that pinocytosis in lymphoid cells has a low capacity.

Authors:  V S Goldmacher; N L Tinnel; B C Nelson
Journal:  J Cell Biol       Date:  1986-04       Impact factor: 10.539
  6 in total

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