Literature DB >> 6218504

Sequence specificity in aflatoxin B1--DNA interactions.

K F Muench, R P Misra, M Z Humayun.   

Abstract

The activated form of aflatoxin B1 (AFB1) causes covalent modification primarily of guanine residues, leading to alkali-labile sites in DNA. A simple extension of the Maxam-Gilbert procedure for sequence analysis permits the identification of alkali-labile sites induced by AFB1 and determination of the frequency of alkali-labile AFB1 modifications at particular sites on a DNA fragment of known sequence. Using this strategy, we have investigated the influence of flanking nucleotide sequences on AFB1 modification in a number of DNA fragments of known sequence. Our results show that certain guanine residues in double-stranded DNA are preferentially attacked by AFB1 over others in a manner predictable from a knowledge of vicinal nucleotide sequences. The observed in vitro sequence specificity is independent of a number of tested parameters and is likely to occur in vivo.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6218504      PMCID： PMC393298          DOI： 10.1073/pnas.80.1.6

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  Aflatoxin B -oxide generated by chemical or enzymic oxidation of aflatoxin B1 causes guanine substitution in nucleic acids.

Authors:  C N Martin; R C Garner
Journal:  Nature       Date:  1977-06-30       Impact factor: 49.962

2.  2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin B1, a major acid hydrolysis product of aflatoxin B1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo.

Authors:  J K Lin; J A Miller; E C Miller
Journal:  Cancer Res       Date:  1977-12       Impact factor: 12.701

3.  Completed DNA sequences and organization of repressor-binding sites in the operators of phage lambda.

Authors:  Z Humayun; A Jeffrey; M Ptashne
Journal:  J Mol Biol       Date:  1977-05-15       Impact factor: 5.469

4.  Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine.

Authors:  A D D'Andrea; W A Haseltine
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

5.  Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.

Authors:  J M Essigmann; R G Croy; A M Nadzan; W F Busby; V N Reinhold; G Büchi; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

6.  Complete nucleotide sequence of the Escherichia coli plasmid pBR322.

Authors:  J G Sutcliffe
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1979

7.  Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.

Authors:  D B Clewell
Journal:  J Bacteriol       Date:  1972-05       Impact factor: 3.490

8.  Construction of a site-specific, deletion-frameshift mutation in an essential gene of bacteriophage phiX174.

Authors:  M Z Humayun; R W Chambers
Journal:  Nature       Date:  1979-04-05       Impact factor: 49.962

9.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

10.  The nucleotide sequence of bacteriophage phiX174.

Authors:  F Sanger; A R Coulson; T Friedmann; G M Air; B G Barrell; N L Brown; J C Fiddes; C A Hutchison; P M Slocombe; M Smith
Journal:  J Mol Biol       Date:  1978-10-25       Impact factor: 5.469
View more
  19 in total

Review 1.  Evolutionary consequences of nonrandom damage and repair of chromatin domains.

Authors:  T Boulikas
Journal:  J Mol Evol       Date:  1992-08       Impact factor: 2.395

2.  AFB(1) -induced mutagenesis of the gpt gene in AS52 cells.

Authors:  Roongtiwa Wattanawaraporn; Min Young Kim; Jillian Adams; Laura J Trudel; Leslie L Woo; Robert G Croy; John M Essigmann; Gerald N Wogan
Journal:  Environ Mol Mutagen       Date:  2012-06-26       Impact factor: 3.216

3.  Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin B1-induced rat liver tumors.

Authors:  G McMahon; E F Davis; L J Huber; Y Kim; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

4.  T4 DNA polymerase (3'-5') exonuclease, an enzyme for the detection and quantitation of stable DNA lesions: the ultraviolet light example.

Authors:  P W Doetsch; G L Chan; W A Haseltine
Journal:  Nucleic Acids Res       Date:  1985-05-10       Impact factor: 16.971

5.  Sequence context effects in DNA replication blocks induced by aflatoxin B1.

Authors:  L M Refolo; M P Conley; K Sambamurti; J S Jacobsen; M Z Humayun
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

6.  Site-specific carcinogen binding to DNA in polytene chromosomes.

Authors:  P D Kurth; M Bustin
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

7.  Quantitation of aflatoxin B1 adduction within the ribosomal RNA gene sequences of rat liver DNA.

Authors:  T R Irvin; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

8.  Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase.

Authors:  J H Yu; T J Leonard
Journal:  J Bacteriol       Date:  1995-08       Impact factor: 3.490

9.  Mutational properties of the primary aflatoxin B1-DNA adduct.

Authors:  E A Bailey; R S Iyer; M P Stone; T M Harris; J M Essigmann
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

10.  Restricted repair of aflatoxin B1 induced damage in alpha DNA of monkey cells.

Authors:  S A Leadon; M E Zolan; P C Hanawalt
Journal:  Nucleic Acids Res       Date:  1983-08-25       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.