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Literature DB >> 22728134

Persister-promoting bacterial toxin TisB produces anion-selective pores in planar lipid bilayers.

Philip A Gurnev¹, Ron Ortenberg, Tobias Dörr, Kim Lewis, Sergey M Bezrukov.

Abstract

We studied membrane activity of the bacterial peptide TisB involved in persister cell formation. TisB and its analogs form multi-state ion-conductive pores in planar lipid bilayers with all states displaying similar anionic selectivity. TisB analogs differing by ±1 elementary charges show corresponding changes in selectivity. Probing TisB pores with poly-(ethylene glycol)s reveals only restricted partitioning even for the smallest polymers, suggesting that the pores are characterized by a relatively small diameter. These findings allow us to suggest that TisB forms clusters of narrow pores that are essential for its mechanism of action. Published by Elsevier B.V.

Entities: Chemical Disease Gene Mutation Species

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Year: 2012 PMID： 22728134 PMCID： PMC3498054 DOI： 10.1016/j.febslet.2012.06.021

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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