Literature DB >> 22682794

Time trends in medication use and expenditures in older patients with rheumatoid arthritis.

Leslie R Harrold1, Daniel Peterson, Ashley J Beard, Jerry H Gurwitz, Becky A Briesacher.   

Abstract

BACKGROUND: We sought to examine how expansions in insurance coverage of nonbiologic and biologic disease-modifying antirheumatic drugs affected the access, costs, and health status of older patients with rheumatoid arthritis.
METHODS: We identified a nationally representative sample of older adults with rheumatoid arthritis in the 2000-2006 Medicare Current Beneficiary Survey (unweighted n=1051). We examined changes in disease-modifying antirheumatic drug use, self-reported health status, functional status (activities of daily living), and total costs and out-of-pocket costs for medical care and prescription drugs. Tests for time trends were conducted using weighted regressions.
RESULTS: Between 2000 and 2006, the proportion of older adults with rheumatoid arthritis who received biologics tripled (4.6% vs 13.2%, P=.01), whereas the proportion of people who used a nonbiologic did not change. During the same period, the proportion of older patients with rheumatoid arthritis rating their health as excellent/good significantly increased (43.0% in 2000 to 55.6% in 2006; P=.015). Significant improvements occurred in activities of daily living measures of functional status. Total prescription drug costs (in 2006 US dollars) increased from $2645 in 2000 to $4685 in 2006, P=.0001, whereas out-of-pocket prescription costs remained constant ($842 in 2000 vs $832 in 2006; P=.68). Total medical costs did not significantly increase ($16,563 in 2000 vs $19,510 in 2006; P=.07).
CONCLUSION: Receipt of biologics in older adults with rheumatoid arthritis increased over a period of time when insurance coverage was expanded without increasing patients' out-of-pocket costs. During this time period, concurrent improvements in self-reported health status and functional status suggest improved arthritis care.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID: 22682794      PMCID: PMC3432666          DOI: 10.1016/j.amjmed.2011.11.014

Source DB:  PubMed          Journal:  Am J Med        ISSN: 0002-9343            Impact factor:   4.965


  30 in total

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2.  Patterns of disease modifying antirheumatic drug use in a Spanish cohort of patients with rheumatoid arthritis.

Authors:  Isidoro Gonzalez-Alvaro; Loreto Carmona; Alejandro Balsa; Raimon Sanmarti; Miguel A Belmonte; Xavier Tena
Journal:  J Rheumatol       Date:  2003-04       Impact factor: 4.666

3.  Cost sharing, family health care burden, and the use of specialty drugs for rheumatoid arthritis.

Authors:  Pinar Karaca-Mandic; Geoffrey F Joyce; Dana P Goldman; Marianne Laouri
Journal:  Health Serv Res       Date:  2010-10       Impact factor: 3.402

4.  Patterns of drug use in rheumatoid arthritis.

Authors:  A Bérard; D H Solomon; J Avorn
Journal:  J Rheumatol       Date:  2000-07       Impact factor: 4.666

5.  Safety of low dose methotrexate in elderly patients with rheumatoid arthritis.

Authors:  B Hirshberg; M Muszkat; O Schlesinger; A Rubinow
Journal:  Postgrad Med J       Date:  2000-12       Impact factor: 2.401

6.  Trends in out-of-pocket medical care expenditures for Medicare-age adults with arthritis between 1998 and 2004.

Authors:  Ithai Z Lurie; Dorothy D Dunlop; Larry M Manheim
Journal:  Arthritis Rheum       Date:  2008-08

7.  The effect of Medicare Part D coverage on drug use and cost sharing among seniors without prior drug benefits.

Authors:  Sebastian Schneeweiss; Amanda R Patrick; Alex Pedan; Laleh Varasteh; Raisa Levin; Nan Liu; William H Shrank
Journal:  Health Aff (Millwood)       Date:  2009-02-03       Impact factor: 6.301

8.  Accuracy of Medicare claims data for rheumatologic diagnoses in total hip replacement recipients.

Authors:  Elena Losina; Jane Barrett; John A Baron; Jeffrey N Katz
Journal:  J Clin Epidemiol       Date:  2003-06       Impact factor: 6.437

9.  Missed opportunities in the treatment of elderly patients with rheumatoid arthritis.

Authors:  Beáta J Radovits; Jaap Fransen; Agnes Eijsbouts; Piet L C M van Riel; Roland F J M Laan
Journal:  Rheumatology (Oxford)       Date:  2009-05-28       Impact factor: 7.580

10.  Impact of Medicare Part D on access to and cost sharing for specialty biologic medications for beneficiaries with rheumatoid arthritis.

Authors:  Jennifer M Polinski; Penny E Mohr; Lorraine Johnson
Journal:  Arthritis Rheum       Date:  2009-06-15
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  13 in total

1.  Medical Care Costs Associated With Rheumatoid Arthritis in the US: A Systematic Literature Review and Meta-Analysis.

Authors:  Andrew Hresko; Tzu-Chieh Lin; Daniel H Solomon
Journal:  Arthritis Care Res (Hoboken)       Date:  2018-10       Impact factor: 4.794

2.  What Strategies Do Physicians and Patients Discuss to Reduce Out-of-Pocket Costs? Analysis of Cost-Saving Strategies in 1,755 Outpatient Clinic Visits.

Authors:  Wynn G Hunter; Cecilia Z Zhang; Ashley Hesson; J Kelly Davis; Christine Kirby; Lillie D Williamson; Jamison A Barnett; Peter A Ubel
Journal:  Med Decis Making       Date:  2016-01-19       Impact factor: 2.583

3.  Population Variations in Rheumatoid Arthritis Treatment and Outcomes, Northern California, 1998-2009.

Authors:  Lisa J Herrinton; Leslie Harrold; Craig Salman; Liyan Liu; Robert Goldfien; Maryam Asgari; Joel M Gelfand; Jashin J Wu; Jeffrey R Curtis
Journal:  Perm J       Date:  2015-12-21

4.  Linkage of a de-identified United States rheumatoid arthritis registry with administrative data to facilitate comparative effectiveness research.

Authors:  Jeffrey R Curtis; Lang Chen; Aseem Bharat; Elizabeth Delzell; Jeffrey D Greenberg; Leslie Harrold; Joel Kremer; Soko Setoguchi; Daniel H Solomon; Fenglong Xie; Huifeng Yun
Journal:  Arthritis Care Res (Hoboken)       Date:  2014-12       Impact factor: 4.794

5.  Discussing Out-of-Pocket Expenses During Clinical Appointments: An Observational Study of Patient-Psychiatrist Interactions.

Authors:  Gregory D Brown; Wynn G Hunter; Ashley Hesson; J Kelly Davis; Christine Kirby; Jamison A Barnett; Dmytro Byelmac; Peter A Ubel
Journal:  Psychiatr Serv       Date:  2017-03-15       Impact factor: 3.084

6.  Sociodemographic Determinants of Out-of-Pocket Expenditures for Patients Using Prescription Drugs for Rheumatoid Arthritis.

Authors:  Kumar Mukherjee; Khalid M Kamal
Journal:  Am Health Drug Benefits       Date:  2017-02

7.  Cost-related medication nonadherence in older patients with rheumatoid arthritis.

Authors:  Leslie R Harrold; Becky A Briesacher; Dan Peterson; Ashley Beard; Jeanne Madden; Fang Zhang; Jerry H Gurwitz; Stephen B Soumerai
Journal:  J Rheumatol       Date:  2013-01-15       Impact factor: 4.666

Review 8.  Rheumatoid arthritis in the elderly in the era of tight control.

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Journal:  Drugs Aging       Date:  2013-11       Impact factor: 3.923

9.  [The first biologic for rheumatoid arthritis: factors influencing the therapeutic decision].

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Journal:  Z Rheumatol       Date:  2017-04       Impact factor: 1.372

10.  Biologics Prescribing for Rheumatoid Arthritis in Older Patients: A Single-Center Retrospective Cross-Sectional Study.

Authors:  Klara Morsley; Thomas Kilner; Alan Steuer
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