Literature DB >> 22551038

Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies.

M S Ramirez1, G Xie, S H Marshall, K M Hujer, P S G Chain, R A Bonomo, M E Tolmasky.   

Abstract

Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the 'high heterogeneity zone' (HHZ). The HHZ consists of several regions, including a 'hot spot' prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.
© 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.

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Year:  2012        PMID： 22551038      PMCID： PMC3377791          DOI： 10.1111/j.1469-0691.2012.03886.x

Source DB:  PubMed          Journal:  Clin Microbiol Infect        ISSN： 1198-743X            Impact factor:   8.067


  21 in total

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Review 5.  Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace.

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Review 6.  Silencing Antibiotic Resistance with Antisense Oligonucleotides.

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7.  Genome Sequences of Two Klebsiella pneumoniae Isolates from Different Geographical Regions, Argentina (Strain JHCK1) and the United States (Strain VA360).

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  10 in total

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