Literature DB >> 3521478

Plasmid-encoded amikacin resistance in multiresistant strains of Klebsiella pneumoniae isolated from neonates with meningitis.

M Woloj, M E Tolmasky, M C Roberts, J H Crosa.   

Abstract

Two multiresistant Klebsiella pneumoniae strains isolated from cerebrospinal fluid of human neonates were analyzed for their plasmid content. Two of the plasmids harbored by these strains, pJHCMW1 (11 kilobase pairs) and pJHCMW4 (75 kilobase pairs), carried genetic determinants for amikacin resistance. These plasmids also encoded resistance to kanamycin, tobramycin, and ampicillin which could be transferred to Escherichia coli by conjugation. Extracts from transconjugant derivatives carrying pJHCMW4 produced an acetyltransferase activity that acetylated all three aminoglycosides. Transconjugant derivatives carrying pJHCMW1 encoded both acetylating and phosphorylating activities. Southern blot hybridization analysis indicated considerable DNA homology between these two plasmids.

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Year:  1986        PMID： 3521478      PMCID： PMC176398          DOI： 10.1128/AAC.29.2.315

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Aminoglycoside-modifying enzymes.

Authors:  M J Haas; J E Dowding
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

5.  A complementation analysis of the restriction and modification of DNA in Escherichia coli.

Authors:  H W Boyer; D Roulland-Dussoix
Journal:  J Mol Biol       Date:  1969-05-14       Impact factor: 5.469

6.  Nucleic acid reassociation in formamide.

Authors:  B L McConaughy; C D Laird; B J McCarthy
Journal:  Biochemistry       Date:  1969-08       Impact factor: 3.162

7.  A membrane-filter technique for the detection of complementary DNA.

Authors:  D T Denhardt
Journal:  Biochem Biophys Res Commun       Date:  1966-06-13       Impact factor: 3.575

8.  Characterization of an R-plasmid associated with ampicillin resistance in Shigella dysenteriae type 1 isolated from epidemics.

Authors:  J H Crosa; J Olarte; L J Mata; L K Luttropp; M E Peñaranda
Journal:  Antimicrob Agents Chemother       Date:  1977-03       Impact factor: 5.191

9.  Treatment of gram-negative bacillary meningitis: role of the new cephalosporin antibiotics.

Authors:  C E Cherubin; M L Corrado; S R Nair; M E Gombert; S Landesman; G Humbert
Journal:  Rev Infect Dis       Date:  1982 Sep-Oct

10.  Gentamicin:adenine mononucleotide transferase: partial purification, characterization, and use in the clinical quantitation of gentamicin.

Authors:  A L Smith; D H Smith
Journal:  J Infect Dis       Date:  1974-04       Impact factor: 5.226
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  33 in total

1.  Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib.

Authors:  A Shmara; N Weinsetel; K J Dery; R Chavideh; M E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

2.  Characterization of Tn6238 with a new allele of aac(6')-Ib-cr.

Authors:  María P Quiroga; Betina Orman; Laura Errecalde; Sara Kaufman; Daniela Centrón
Journal:  Antimicrob Agents Chemother       Date:  2015-02-17       Impact factor: 5.191

3.  Sequencing and expression of the 6'-N-acetyltransferase gene of transposon Tn1331 from Klebsiella pneumoniae.

Authors:  K Nobuta; M E Tolmasky; L M Crosa; J H Crosa
Journal:  J Bacteriol       Date:  1988-08       Impact factor: 3.490

4.  Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides.

Authors:  R Chavideh; S Sholly; D Panaite; M E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

Review 5.  Is antimicrobial resistance in hospital microorganisms related to antibiotic use?

Authors:  J E McGowan
Journal:  Bull N Y Acad Med       Date:  1987-04

6.  Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae.

Authors:  M E Tolmasky; J H Crosa
Journal:  Antimicrob Agents Chemother       Date:  1987-12       Impact factor: 5.191

Review 7.  Use of plasmid profiles in epidemiologic surveillance of disease outbreaks and in tracing the transmission of antibiotic resistance.

Authors:  L W Mayer
Journal:  Clin Microbiol Rev       Date:  1988-04       Impact factor: 26.132

8.  Differences in resolution of mwr-containing plasmid dimers mediated by the Klebsiella pneumoniae and Escherichia coli XerC recombinases: potential implications in dissemination of antibiotic resistance genes.

Authors:  Duyen Bui; Judianne Ramiscal; Sonia Trigueros; Jason S Newmark; Albert Do; David J Sherratt; Marcelo E Tolmasky
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

9.  Identification of an Inhibitor of the Aminoglycoside 6'-N-Acetyltransferase type Ib [AAC(6')-Ib] by Glide Molecular Docking.

Authors:  Kevin Chiem; Saumya Jani; Brooke Fuentes; David L Lin; Madeline E Rasche; Marcelo E Tolmasky
Journal:  Medchemcomm       Date:  2015-11-03       Impact factor: 3.597

10.  Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance by antisense oligodeoxynucleotides.

Authors:  Renee Sarno; Hongphuc Ha; Natalia Weinsetel; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191
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