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Literature DB >> 22547105

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues.

Diana Matthes¹, Lennart Richter, Jane Müller, Alexander Denisiuk, Sven C Feifel, Yuquan Xu, Patricia Espinosa-Artiles, Roderich D Süssmuth, István Molnár.

Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Entities: Chemical Species

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Year: 2012 PMID： 22547105 DOI： 10.1039/c2cc31669b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

14 in total

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In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues.

1. Identifying the Minimal Enzymes Required for Biosynthesis of Epoxyketone Proteasome Inhibitors.

Review 2. Harnessing natural product assembly lines: structure, promiscuity, and engineering.

3. Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

4. Scale-up bioprocess development for production of the antibiotic valinomycin in Escherichia coli based on consistent fed-batch cultivations.

5. An economical and safe procedure to synthesize 2-hydroxy-4-pentynoic acid: A precursor towards 'clickable' biodegradable polylactide.

6. Bacillus subtilis as heterologous host for the secretory production of the non-ribosomal cyclodepsipeptide enniatin.

7. Engineering of Aspergillus niger for the production of secondary metabolites.

8. Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides.

9. Endophytes as producers of peptides: an overview about the recently discovered peptides from endophytic microbes.

10. Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry.