Literature DB >> 22545061

Novel neutron sources at the Radiological Research Accelerator Facility.

Yanping Xu1, Guy Garty, Stephen A Marino, Thomas N Massey, Gerhard Randers-Pehrson, Gary W Johnson, David J Brenner.   

Abstract

Since the 1960s, the Radiological Research Accelerator Facility (RARAF) has been providing researchers in biology, chemistry and physics with advanced irradiation techniques, using charged particles, photons and neutrons.We are currently developing a unique facility at RARAF, to simulate neutron spectra from an improvised nuclear device (IND), based on calculations of the neutron spectrum at 1.5 km from the epicenter of the Hiroshima atom bomb. This is significantly different from a standard fission spectrum, because the spectrum changes as the neutrons are transported through air, and is dominated by neutron energies between 0.05 and 8 MeV. This facility will be based on a mixed proton/deuteron beam impinging on a thick beryllium target.A second, novel facility under development is our new neutron microbeam. The neutron microbeam will, for the first time, provide a kinematically collimated neutron beam, 10-20 micron in diameter. This facility is based on a Proton Microbeam, impinging on a thin lithium target near the threshold of the (7)Li(p,n)(7)Be reaction. This novel neutron microbeam will enable studies of neutron damage to small targets, such as single cells, individual organs within small animals or microelectronic components.

Entities:  

Year:  2012        PMID: 22545061      PMCID: PMC3337765          DOI: 10.1088/1748-0221/7/03/C03031

Source DB:  PubMed          Journal:  J Instrum        ISSN: 1748-0221            Impact factor:   1.415


  12 in total

1.  Oncogenic transformation in C3H10T1/2 cells by low-energy neutrons.

Authors:  R C Miller; S A Marino; J Napoli; H Shah; E J Hall; C R Geard; D J Brenner
Journal:  Int J Radiat Biol       Date:  2000-03       Impact factor: 2.694

2.  The Columbia University single-ion microbeam.

Authors:  G Randers-Pehrson; C R Geard; G Johnson; C D Elliston; D J Brenner
Journal:  Radiat Res       Date:  2001-08       Impact factor: 2.841

3.  An accelerator-based neutron microbeam system for studies of radiation effects.

Authors:  Yanping Xu; Gerhard Randers-Pehrson; Stephen A Marino; Alan W Bigelow; Mark S Akselrod; Jeff G Sykora; David J Brenner
Journal:  Radiat Prot Dosimetry       Date:  2010-12-03       Impact factor: 0.972

4.  The Columbia University proton-induced soft x-ray microbeam.

Authors:  Andrew D Harken; Gerhard Randers-Pehrson; Gary W Johnson; David J Brenner
Journal:  Nucl Instrum Methods Phys Res B       Date:  2011-09-15       Impact factor: 1.377

5.  Measurement of the 9Be(p,n) thick target spectrum for use in accelerator-based boron neutron capture therapy.

Authors:  W B Howard; J C Yanch; S M Grimes; T N Massey; S I al-Quraishi; D K Jacobs; C E Brient
Journal:  Med Phys       Date:  1996-07       Impact factor: 4.071

6.  Neoplastic transformation of mouse C3H10T1/2 cells following exposure to neutrons does not involve mutation of ras gene as analyzed by SSCP and cycle sequencing.

Authors:  G A Freyer; D A Palmer; Y Yu; R C Miller; T K Pandita
Journal:  Mutat Res       Date:  1996-10-25       Impact factor: 2.433

7.  Quantitative assessment of the cataractogenic potential of very low doses of neutrons.

Authors:  B V Worgul; C Medvedovsky; Y Huang; S A Marino; G Randers-Pehrson; D J Brenner
Journal:  Radiat Res       Date:  1996-03       Impact factor: 2.841

8.  Neutron RBEs for cytopenia and repopulation of stroma and hematopoietic stem cells: mathematical models of marrow cell kinetics.

Authors:  T D Jones; M D Morris; R W Young; R A Kehlet
Journal:  Health Phys       Date:  1997-04       Impact factor: 1.316

9.  Malignant transformation in cultured hamster embryo cells produced by X-rays, 460-keV monoenergetic neutrons, and heavy ions.

Authors:  C Borek; E J Hall; H H Rossi
Journal:  Cancer Res       Date:  1978-09       Impact factor: 12.701

10.  The r.b.e. of different energy neutrons as measured by the heamatopoietic spleen-colony technique.

Authors:  A L Carsten; V P Bond; K Thompson
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1976-01
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  6 in total

1.  Broad Energy Range Neutron Spectroscopy using a Liquid Scintillator and a Proportional Counter: Application to a Neutron Spectrum Similar to that from an Improvised Nuclear Device.

Authors:  Yanping Xu; Gerhard Randers-Pehrson; Stephen A Marino; Guy Garty; Andrew Harken; David J Brenner
Journal:  Nucl Instrum Methods Phys Res A       Date:  2015-09-11       Impact factor: 1.455

2.  Metabolic oxygen consumption measurement with a single-cell biosensor after particle microbeam irradiation.

Authors:  Yanping Xu; Bo Zhang; Mark Messerli; Gerhard Randers-Pehrson; Tom K Hei; David J Brenner
Journal:  Radiat Environ Biophys       Date:  2014-10-22       Impact factor: 1.925

3.  Cytogenetic Damage of Human Lymphocytes in Humanized Mice Exposed to Neutrons and X Rays 24 h After Exposure.

Authors:  Qi Wang; Younghyun Lee; Monica Pujol-Canadell; Jay R Perrier; Lubomir Smilenov; Andrew Harken; Guy Garty; David J Brenner; Brian Ponnaiya; Helen C Turner
Journal:  Cytogenet Genome Res       Date:  2021-09-06       Impact factor: 1.941

4.  Accelerator-Based Biological Irradiation Facility Simulating Neutron Exposure from an Improvised Nuclear Device.

Authors:  Yanping Xu; Gerhard Randers-Pehrson; Helen C Turner; Stephen A Marino; Charles R Geard; David J Brenner; Guy Garty
Journal:  Radiat Res       Date:  2015-09-28       Impact factor: 2.841

5.  Small Molecule Responses to Sequential Irradiation with Neutrons and Photons for Biodosimetry Applications: An Initial Assessment.

Authors:  Evagelia C Laiakis; Monica Pujol Canadell; Veljko Grilj; Andrew D Harken; Guy Y Garty; David J Brenner; Lubomir Smilenov; Albert J Fornace
Journal:  Radiat Res       Date:  2021-11-01       Impact factor: 2.841

6.  Machine learning methodology for high throughput personalized neutron dose reconstruction in mixed neutron + photon exposures.

Authors:  Igor Shuryak; Helen C Turner; Monica Pujol-Canadell; Jay R Perrier; Guy Garty; David J Brenner
Journal:  Sci Rep       Date:  2021-02-17       Impact factor: 4.379

  6 in total

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