Literature DB >> 22484319

Crystal structure of a group II intron in the pre-catalytic state.

Russell T Chan1, Aaron R Robart, Kanagalaghatta R Rajashankar, Anna Marie Pyle, Navtej Toor.   

Abstract

Group II introns are self-splicing catalytic RNAs that are thought to be ancestral to the spliceosome. Here we report the 3.65-Å crystal structure of the group II intron from Oceanobacillus iheyensis in the pre-catalytic state. The structure reveals the conformation of the 5' splice site in the catalytic core and represents the first structure of an intron prior to the first step of splicing.

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Year:  2012        PMID： 22484319      PMCID： PMC3670821          DOI： 10.1038/nsmb.2270

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  18 in total

1.  A three-dimensional perspective on exon binding by a group II self-splicing intron.

Authors:  M Costa; F Michel; E Westhof
Journal:  EMBO J       Date:  2000-09-15       Impact factor: 11.598

2.  Principles of 3' splice site selection and alternative splicing for an unusual group II intron from Bacillus anthracis.

Authors:  Aaron R Robart; Nancy Kristine Montgomery; Kimothy L Smith; Steven Zimmerly
Journal:  RNA       Date:  2004-05       Impact factor: 4.942

3.  A single active-site region for a group II intron.

Authors:  Alexandre de Lencastre; Stephanie Hamill; Anna Marie Pyle
Journal:  Nat Struct Mol Biol       Date:  2005-06-26       Impact factor: 15.369

Review 4.  Group II intron retroelements: function and diversity.

Authors:  A R Robart; S Zimmerly
Journal:  Cytogenet Genome Res       Date:  2005       Impact factor: 1.636

5.  Introns and the origin of nucleus-cytosol compartmentalization.

Authors:  William Martin; Eugene V Koonin
Journal:  Nature       Date:  2006-03-02       Impact factor: 49.962

6.  Crystal structure of a self-spliced group II intron.

Authors:  Navtej Toor; Kevin S Keating; Sean D Taylor; Anna Marie Pyle
Journal:  Science       Date:  2008-04-04       Impact factor: 47.728

Review 7.  Intron-dominated genomes of early ancestors of eukaryotes.

Authors:  Eugene V Koonin
Journal:  J Hered       Date:  2009-07-17       Impact factor: 2.645

8.  Multiple exon-binding sites in class II self-splicing introns.

Authors:  A Jacquier; F Michel
Journal:  Cell       Date:  1987-07-03       Impact factor: 41.582

9.  Effects of maturase binding and Mg2+ concentration on group II intron RNA folding investigated by UV cross-linking.

Authors:  James W Noah; Alan M Lambowitz
Journal:  Biochemistry       Date:  2003-11-04       Impact factor: 3.162

10.  Structural basis for exon recognition by a group II intron.

Authors:  Navtej Toor; Kanagalaghatta Rajashankar; Kevin S Keating; Anna Marie Pyle
Journal:  Nat Struct Mol Biol       Date:  2008-10-26       Impact factor: 15.369
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  24 in total

1.  RNA folding: A clear path to RNA catalysis.

Authors:  Amanda Solem; Alain Laederach
Journal:  Nat Chem Biol       Date:  2015-12       Impact factor: 15.040

2.  RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.

Authors:  Maria Anokhina; Sergey Bessonov; Zhichao Miao; Eric Westhof; Klaus Hartmuth; Reinhard Lührmann
Journal:  EMBO J       Date:  2013-09-03       Impact factor: 11.598

3.  Emerging views about the molecular structure of the spliceosomal catalytic center.

Authors:  Jana Schmitzová; Vladimir Pena
Journal:  RNA Biol       Date:  2012-10-12       Impact factor: 4.652

Review 4.  Structural Insights into the Mechanism of Group II Intron Splicing.

Authors:  Chen Zhao; Anna Marie Pyle
Journal:  Trends Biochem Sci       Date:  2017-04-21       Impact factor: 13.807

5.  The role of Mg(II) in DNA cleavage site recognition in group II intron ribozymes: solution structure and metal ion binding sites of the RNA-DNA complex.

Authors:  Miriam Skilandat; Roland K O Sigel
Journal:  J Biol Chem       Date:  2014-07-25       Impact factor: 5.157

Review 6.  Structure and function of the T-loop structural motif in noncoding RNAs.

Authors:  Clarence W Chan; Bhaskar Chetnani; Alfonso Mondragón
Journal:  Wiley Interdiscip Rev RNA       Date:  2013-06-10       Impact factor: 9.957

7.  The structural stabilization of the κ three-way junction by Mg(II) represents the first step in the folding of a group II intron.

Authors:  Daniela Donghi; Maria Pechlaner; Cinzia Finazzo; Bernd Knobloch; Roland K O Sigel
Journal:  Nucleic Acids Res       Date:  2012-12-28       Impact factor: 16.971

8.  Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing.

Authors:  Raphael Plangger; Michael Andreas Juen; Thomas Philipp Hoernes; Felix Nußbaumer; Johannes Kremser; Elisabeth Strebitzer; David Klingler; Kevin Erharter; Martin Tollinger; Matthias David Erlacher; Christoph Kreutz
Journal:  Nucleic Acids Res       Date:  2019-12-02       Impact factor: 16.971

9.  Visualizing group II intron catalysis through the stages of splicing.

Authors:  Marco Marcia; Anna Marie Pyle
Journal:  Cell       Date:  2012-10-26       Impact factor: 41.582

Review 10.  Mss116p: a DEAD-box protein facilitates RNA folding.

Authors:  Nora Sachsenmaier; Christina Waldsich
Journal:  RNA Biol       Date:  2012-10-12       Impact factor: 4.652
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