PURPOSE: To examine which cognitive, environmental, and speech-language variables predict expressive syntax in boys with fragile X syndrome (FXS), boys with Down syndrome (DS), and typically developing (TD) boys, and whether predictive relationships differed by group. METHOD: We obtained Index of Productive Syntax ( Scarborough, 1990) scores for 18 boys with FXS only, 20 boys with both FXS and an autism spectrum disorder, 27 boys with DS, and 25 younger TD boys of similar nonverbal mental age. Predictors included group (diagnosis), nonverbal cognition, phonological working memory (PWM), maternal education, speech intelligibility, and expressive vocabulary. The research questions were addressed via hierarchical linear regression. RESULTS: Diagnostic group, nonverbal cognition, and PWM predicted 56% of the variance in syntactic ability, with approximately three-fourths of the predicted variance explained by group membership alone. The other factors did not contribute any additional significant variance in this final model. There was no evidence that predictor effects differed by group. CONCLUSIONS: Nonverbal cognition and PWM have an effect on expressive syntax beyond that of diagnostic group. These effects are estimated to be the same in boys with FXS, boys with DS, and TD boys. Explanations for residual variance and the relative role of different predictors are discussed.
PURPOSE: To examine which cognitive, environmental, and speech-language variables predict expressive syntax in boys with fragile X syndrome (FXS), boys with Down syndrome (DS), and typically developing (TD) boys, and whether predictive relationships differed by group. METHOD: We obtained Index of Productive Syntax ( Scarborough, 1990) scores for 18 boys with FXS only, 20 boys with both FXS and an autism spectrum disorder, 27 boys with DS, and 25 younger TD boys of similar nonverbal mental age. Predictors included group (diagnosis), nonverbal cognition, phonological working memory (PWM), maternal education, speech intelligibility, and expressive vocabulary. The research questions were addressed via hierarchical linear regression. RESULTS: Diagnostic group, nonverbal cognition, and PWM predicted 56% of the variance in syntactic ability, with approximately three-fourths of the predicted variance explained by group membership alone. The other factors did not contribute any additional significant variance in this final model. There was no evidence that predictor effects differed by group. CONCLUSIONS: Nonverbal cognition and PWM have an effect on expressive syntax beyond that of diagnostic group. These effects are estimated to be the same in boys with FXS, boys with DS, and TD boys. Explanations for residual variance and the relative role of different predictors are discussed.
Authors: Thomas F Campbell; Christine A Dollaghan; Howard E Rockette; Jack L Paradise; Heidi M Feldman; Lawrence D Shriberg; Diane L Sabo; Marcia Kurs-Lasky Journal: Child Dev Date: 2003 Mar-Apr
Authors: Leonard Abbeduto; Melissa M Murphy; Stephanie W Cawthon; Erica K Richmond; Michelle D Weissman; Selma Karadottir; Anne O'Brien Journal: Am J Ment Retard Date: 2003-05
Authors: Bronwyn Glaser; David Hessl; Jennifer Dyer-Friedman; Cindy Johnston; Jacob Wisbeck; Annette Taylor; Allan Reiss Journal: Am J Med Genet A Date: 2003-02-15 Impact factor: 2.802
Authors: Elizabeth Berry-Kravis; David Hessl; Leonard Abbeduto; Allan L Reiss; Andrea Beckel-Mitchener; Tiina K Urv Journal: J Dev Behav Pediatr Date: 2013-09 Impact factor: 2.225
Authors: Andrea McDuffie; Wendy Machalicek; Lauren Bullard; Sarah Nelson; Melissa Mello; Robyn Tempero-Feigles; Nancy Castignetti; Leonard Abbeduto Journal: Am J Intellect Dev Disabil Date: 2016-05