Literature DB >> 22451742

APPLICATIONS OF MULTICOMPONENT ASSEMBLY PROCESSES TO THE FACILE SYNTHESES OF DIVERSELY FUNCTIONALIZED NITROGEN HETEROCYCLES.

James R Donald1, Brett A Granger, Simon Hardy, James J Sahn, Stephen F Martin.   

Abstract

Several multicomponent assembly processes have been developed for the synthesis of intermediates that may be elaborated by a variety of cyclizations to generate a diverse array of highly functionalized heterocycles from readily-available starting materials. The overall approach enables the efficient preparation of libraries of small molecules derived from fused, privileged scaffolds.

Entities:  

Year:  2011        PMID： 22451742      PMCID： PMC3311471          DOI： 10.3987/COM-11-S(P)92

Source DB:  PubMed          Journal:  Heterocycles        ISSN： 0385-5414            Impact factor:   0.831


  25 in total

1.  Facile and unified approach to skeletally diverse, privileged scaffolds.

Authors:  James J Sahn; Justin Y Su; Stephen F Martin
Journal:  Org Lett       Date:  2011-04-22       Impact factor: 6.005

2.  Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

Authors:  Brett A Granger; Kyosuke Kaneda; Stephen F Martin
Journal:  Org Lett       Date:  2011-08-11       Impact factor: 6.005

Review 3.  2-Azetidinone--a new profile of various pharmacological activities.

Authors:  Parul D Mehta; N P S Sengar; A K Pathak
Journal:  Eur J Med Chem       Date:  2010-09-27       Impact factor: 6.514

4.  Synthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.

Authors:  James D Sunderhaus; Chris Dockendorff; Stephen F Martin
Journal:  Tetrahedron       Date:  2009-09-15       Impact factor: 2.457

5.  Stachyflin and acetylstachyflin, novel anti-influenza A virus substances, produced by Stachybotrys sp. RF-7260. II. Synthesis and preliminary structure-activity relationships of stachyflin derivatives.

Authors:  Kazuyuki Minagawa; Shuichi Kouzuki; Toshiyuki Kamigauchi
Journal:  J Antibiot (Tokyo)       Date:  2002-02       Impact factor: 2.649

6.  Praziquantel analogs with activity against juvenile Schistosoma mansoni.

Authors:  Yuxiang Dong; Jacques Chollet; Mireille Vargas; Nuha R Mansour; Quentin Bickle; Yazen Alnouti; Jiangeng Huang; Jennifer Keiser; Jonathan L Vennerstrom
Journal:  Bioorg Med Chem Lett       Date:  2010-03-04       Impact factor: 2.823

Review 7.  Privileged scaffolds for library design and drug discovery.

Authors:  Matthew E Welsch; Scott A Snyder; Brent R Stockwell
Journal:  Curr Opin Chem Biol       Date:  2010-03-18       Impact factor: 8.822

8.  Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.

Authors:  Y L Chen; D Liston; J Nielsen; D Chapin; A Dunaiskis; K Hedberg; J Ives; J Johnson; S Jones
Journal:  J Med Chem       Date:  1994-06-24       Impact factor: 7.446

9.  Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds.

Authors:  James D Sunderhaus; Stephen F Martin
Journal:  Chemistry       Date:  2009       Impact factor: 5.236

10.  1,2,3-Triazolo[1,5-a][1,4]- and 1,2,3-triazolo[1,5-a]-[1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding.

Authors:  L Bertelli; G Biagi; I Giorgi; O Livi; C Manera; V Scartoni; C Martini; G Giannaccini; L Trincavelli; P L Barili
Journal:  Farmaco       Date:  1998-04
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  7 in total

1.  Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines.

Authors:  James R Donald; Rebekah R Wood; Stephen F Martin
Journal:  ACS Comb Sci       Date:  2012-02-01       Impact factor: 3.784

2.  Multicomponent, Mannich-type assembly process for generating novel, biologically-active 2-arylpiperidines and derivatives.

Authors:  Simon Hardy; Stephen F Martin
Journal:  Tetrahedron       Date:  2014-10-07       Impact factor: 2.457

3.  Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy.

Authors:  Brett A Granger; Kyosuke Kaneda; Stephen F Martin
Journal:  ACS Comb Sci       Date:  2011-11-10       Impact factor: 3.784

Review 4.  Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification.

Authors:  James J Sahn; Brett A Granger; Stephen F Martin
Journal:  Org Biomol Chem       Date:  2014-08-19       Impact factor: 3.876

5.  Applications of Ring Closing Metathesis. Total Synthesis of (±)-Pseudotabersonine.

Authors:  Bo Cheng; James D Sunderhaus; Stephen F Martin
Journal:  Tetrahedron       Date:  2015-09-30       Impact factor: 2.457

6.  Multicomponent assembly processes for the synthesis of diverse yohimbine and corynanthe alkaloid analogues.

Authors:  Brett A Granger; Zhiqian Wang; Kyosuke Kaneda; Zhenglai Fang; Stephen F Martin
Journal:  ACS Comb Sci       Date:  2013-06-04       Impact factor: 3.784

7.  Expedient synthesis of norbenzomorphan library via multicomponent assembly process coupled with ring-closing reactions.

Authors:  James J Sahn; Stephen F Martin
Journal:  ACS Comb Sci       Date:  2012-08-20       Impact factor: 3.784
  7 in total

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