Literature DB >> 22857149

Expedient synthesis of norbenzomorphan library via multicomponent assembly process coupled with ring-closing reactions.

James J Sahn1, Stephen F Martin.   

Abstract

A 124-member norbenzomorphan library has been prepared utilizing a novel multicomponent assembly process (MCAP) followed by a variety of ring-closing reactions to generate norbenzomorphan scaffolds that were readily derivatized via a series of aryl halide cross-coupling and nitrogen functionalization reactions. Biological screening has revealed some novel activities that have not been previously associated with this class of compounds.

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Year:  2012        PMID： 22857149      PMCID： PMC3508166          DOI： 10.1021/co300068a

Source DB:  PubMed          Journal:  ACS Comb Sci        ISSN： 2156-8944            Impact factor:   3.784


  29 in total

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Review 3.  Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology.

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6.  Synthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.

Authors:  James D Sunderhaus; Chris Dockendorff; Stephen F Martin
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Review 9.  Privileged scaffolds for library design and drug discovery.

Authors:  Matthew E Welsch; Scott A Snyder; Brent R Stockwell
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10.  Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.

Authors:  Y L Chen; D Liston; J Nielsen; D Chapin; A Dunaiskis; K Hedberg; J Ives; J Johnson; S Jones
Journal:  J Med Chem       Date:  1994-06-24       Impact factor: 7.446
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  15 in total

1.  Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands.

Authors:  James J Sahn; Timothy R Hodges; Jessica Z Chan; Stephen F Martin
Journal:  ChemMedChem       Date:  2016-02-24       Impact factor: 3.466

2.  Natural Products and Their Mimics as Targets of Opportunity for Discovery.

Authors:  Stephen F Martin
Journal:  J Org Chem       Date:  2017-09-15       Impact factor: 4.354

3.  Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.

Authors:  Bitna Yi; James J Sahn; Pooneh Memar Ardestani; Andrew K Evans; Luisa L Scott; Jessica Z Chan; Sangeetha Iyer; Ashley Crisp; Gabriella Zuniga; Jonathan T Pierce; Stephen F Martin; Mehrdad Shamloo
Journal:  J Neurochem       Date:  2017-02       Impact factor: 5.372

4.  Multicomponent, Mannich-type assembly process for generating novel, biologically-active 2-arylpiperidines and derivatives.

Authors:  Simon Hardy; Stephen F Martin
Journal:  Tetrahedron       Date:  2014-10-07       Impact factor: 2.457

5.  High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model.

Authors:  Sudip Mondal; Evan Hegarty; James J Sahn; Luisa L Scott; Sertan Kutal Gökçe; Chris Martin; Navid Ghorashian; Praveen Navoda Satarasinghe; Sangeetha Iyer; Wisath Sae-Lee; Timothy R Hodges; Jonathan T Pierce; Stephen F Martin; Adela Ben-Yakar
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6.  Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors.

Authors:  Luisa L Scott; James J Sahn; Antonio Ferragud; Rachel C Yen; Praveen N Satarasinghe; Michael D Wood; Timothy R Hodges; Ted Shi; Brooke A Prakash; Kaitlyn M Friese; Angela Shen; Valentina Sabino; Jonathan T Pierce; Stephen F Martin
Journal:  Neuropsychopharmacology       Date:  2018-04-20       Impact factor: 7.853

7.  Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury.

Authors:  Edwin Vázquez-Rosa; Michael R Watson; James J Sahn; Timothy R Hodges; Rachel E Schroeder; Coral J Cintrón-Pérez; Min-Kyoo Shin; Terry C Yin; Josie L Emery; Stephen F Martin; Daniel J Liebl; Andrew A Pieper
Journal:  ACS Chem Neurosci       Date:  2018-12-03       Impact factor: 4.418

Review 8.  Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification.

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9.  Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity.

Authors:  James J Sahn; Timothy R Hodges; Jessica Z Chan; Stephen F Martin
Journal:  ACS Med Chem Lett       Date:  2017-03-21       Impact factor: 4.345

10.  Applications of Ring Closing Metathesis. Total Synthesis of (±)-Pseudotabersonine.

Authors:  Bo Cheng; James D Sunderhaus; Stephen F Martin
Journal:  Tetrahedron       Date:  2015-09-30       Impact factor: 2.457
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