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Literature DB >> 20303320

Privileged scaffolds for library design and drug discovery.

Matthew E Welsch¹, Scott A Snyder, Brent R Stockwell.

Abstract

This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2010 PMID： 20303320 PMCID： PMC2908274 DOI： 10.1016/j.cbpa.2010.02.018

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

41 in total

Review 1. Target-oriented and diversity-oriented organic synthesis in drug discovery.

Authors: S L Schreiber
Journal: Science Date: 2000-03-17 Impact factor: 47.728

Review 2. The evolving role of natural products in drug discovery.

Authors: Frank E Koehn; Guy T Carter
Journal: Nat Rev Drug Discov Date: 2005-03 Impact factor: 84.694

Review 3. Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors: David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal: Nat Rev Drug Discov Date: 2006-12-08 Impact factor: 84.694

4. Combinatorial library synthesis and biological evaluation of pyrazolo[4,3-e][1,4]diazepine as a potential privileged structure.

Authors: Ju-Yeon Lee; Yong-Chul Kim
Journal: ChemMedChem Date: 2009-05 Impact factor: 3.466

5. Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways.

Authors: Rajamohan R Poondra; N Niranjan Kumar; Krikor Bijian; Michael Prakesch; Valérie Campagna-Slater; Ayub Reayi; P Thirupathi Reddy; Asna Choudhry; Michael L Barnes; Donald M Leek; Malgosia Daroszewska; Caroline Lougheed; Bin Xu; Matthieu Schapira; Moulay A Alaoui-Jamali; Prabhat Arya
Journal: J Comb Chem Date: 2009-03-09

6. Natural compounds: leads or ideas? Bioinspired molecules for drug discovery.

Authors: Terence Beghyn; Rebecca Deprez-Poulain; Nicolas Willand; Benoit Folleas; Benoit Deprez
Journal: Chem Biol Drug Des Date: 2008-06-11 Impact factor: 2.817

Review 7. From nature to drug discovery: the indole scaffold as a 'privileged structure'.

Authors: Fernando Rodrigues de Sá Alves; Eliezer J Barreiro; Carlos Alberto Manssour Fraga
Journal: Mini Rev Med Chem Date: 2009-06 Impact factor: 3.862

8. The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.

Authors: B A Bunin; M J Plunkett; J A Ellman
Journal: Proc Natl Acad Sci U S A Date: 1994-05-24 Impact factor: 11.205

Review 9. 2-Arylbenzothiazole as a privileged scaffold in drug discovery.

Authors: A A Weekes; A D Westwell
Journal: Curr Med Chem Date: 2009 Impact factor: 4.530

10. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

Authors: N S Gray; L Wodicka; A M Thunnissen; T C Norman; S Kwon; F H Espinoza; D O Morgan; G Barnes; S LeClerc; L Meijer; S H Kim; D J Lockhart; P G Schultz
Journal: Science Date: 1998-07-24 Impact factor: 47.728

216 in total

1. An allenic Pauson-Khand approach to 6,12-guaianolides.

Authors: Francois Grillet; Chaofeng Huang; Kay M Brummond
Journal: Org Lett Date: 2011-11-09 Impact factor: 6.005

2. Synthesis and diversification of 1,2,3-triazole-fused 1,4-benzodiazepine scaffolds.

Authors: James R Donald; Stephen F Martin
Journal: Org Lett Date: 2011-01-28 Impact factor: 6.005

3. Facile and unified approach to skeletally diverse, privileged scaffolds.

Authors: James J Sahn; Justin Y Su; Stephen F Martin
Journal: Org Lett Date: 2011-04-22 Impact factor: 6.005

4. Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

Authors: Brett A Granger; Kyosuke Kaneda; Stephen F Martin
Journal: Org Lett Date: 2011-08-11 Impact factor: 6.005

5. Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines.

Authors: James R Donald; Rebekah R Wood; Stephen F Martin
Journal: ACS Comb Sci Date: 2012-02-01 Impact factor: 3.784

6. Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists.

Authors: David Rodríguez; Saibal Chakraborty; Eugene Warnick; Steven Crane; Zhan-Guo Gao; Robert O'Connor; Kenneth A Jacobson; Jens Carlsson
Journal: ACS Chem Biol Date: 2016-08-22 Impact factor: 5.100

7. Cyclosulfamide-based derivatives as inhibitors of noroviruses.

Authors: Dengfeng Dou; Sivakoteswara R Mandadapu; Kevin R Alliston; Yunjeong Kim; Kyeong-Ok Chang; William C Groutas
Journal: Eur J Med Chem Date: 2011-10-20 Impact factor: 6.514

8. A simple one-pot 2-step N-1-alkylation of indoles with α-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles.

Authors: Guillermo Martinez-Ariza; Muhammad Ayaz; Christopher Hulme
Journal: Tetrahedron Lett Date: 2013-12-04 Impact factor: 2.415

9. Cycloisomerization of Olefins in Water.

Authors: Jeishla L M Matos; Samantha A Green; Yuge Chun; Vuong Q Dang; Russell G Dushin; Paul Richardson; Jason S Chen; David W Piotrowski; Brian M Paegel; Ryan A Shenvi
Journal: Angew Chem Int Ed Engl Date: 2020-05-28 Impact factor: 15.336

Review 10. Tetrazoles via Multicomponent Reactions.

Authors: Constantinos G Neochoritis; Ting Zhao; Alexander Dömling
Journal: Chem Rev Date: 2019-02-01 Impact factor: 60.622