| Literature DB >> 8027982 |
Y L Chen1, D Liston, J Nielsen, D Chapin, A Dunaiskis, K Hedberg, J Ives, J Johnson, S Jones.
Abstract
The synthesis of a series of alkylcarbamates of 1,5-methano-2,3,4,5-tetrahydro-1H-2-benzazepin-7-ol is reported. Many of these compounds are potent acetylcholinesterase (AChE) inhibitors. The in vitro AChE inhibition, cholinergic effects, acute toxicity, and elevation of brain acetylcholine levels in vivo of this series of compounds are described. A representative compound, 1d (5.6 mg/kg, po), was able to reverse hemicolinium-3-induced amnesia in the mouse passive avoidance assay.Entities:
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Year: 1994 PMID： 8027982 DOI： 10.1021/jm00039a013
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446