Literature DB >> 22372979

Nuclease activity via self-activation and anticancer activity of a mononuclear copper(II) complex: novel role of the tertiary butyl group in the ligand frame.

Kaushik Ghosh1, Pramod Kumar, Varun Mohan, Udai P Singh, Sahba Kasiri, Subhrangsu S Mandal.   

Abstract

The copper complex [Cu((t)BuPhimp)(Cl)] (1) derived from tridentate ligand (t)BuPhimpH having N(2)O donors was synthesized, and its molecular structure was determined. A phenoxyl radical complex was generated in solution at room temperature using Ce(IV). The nuclease and anticancer activities of 1 were investigated. The roles of the tert-butyl group and singlet oxygen in the DNA cleavage activity were also discussed.
© 2012 American Chemical Society

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Year:  2012        PMID： 22372979      PMCID： PMC3307853          DOI： 10.1021/ic2016676

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  26 in total

1.  Visible light-induced nuclease activity of a ternary mono-phenanthroline copper(II) complex containing L-methionine as a photosensitizer.

Authors:  Ashis K Patra; Shanta Dhar; Munirathinam Nethaji; Akhil R Chakravarty
Journal:  Chem Commun (Camb)       Date:  2003-07-07       Impact factor: 6.222

2.  "Self-activating" chemical nuclease: ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant.

Authors:  Kun Li; Li-Hong Zhou; Ji Zhang; Shan-Yong Chen; Zhong-Wei Zhang; Jing-Jing Zhang; Hong-Hui Lin; Xiao-Qi Yu
Journal:  Eur J Med Chem       Date:  2008-04-04       Impact factor: 6.514

Review 3.  Activation of DNA carbon-hydrogen bonds by metal complexes.

Authors:  Marguerite Pitié; Geneviève Pratviel
Journal:  Chem Rev       Date:  2010-02-10       Impact factor: 60.622

4.  Synthesis and reactivity studies on new copper(II) complexes: DNA binding, generation of phenoxyl radical, SOD and nuclease activities.

Authors:  Kaushik Ghosh; Pramod Kumar; Nidhi Tyagi; Udai P Singh; Vaibhave Aggarwal; Maria Camilla Baratto
Journal:  Eur J Med Chem       Date:  2010-05-19       Impact factor: 6.514

Review 5.  Bleomycins: towards better therapeutics.

Authors:  Jingyang Chen; JoAnne Stubbe
Journal:  Nat Rev Cancer       Date:  2005-02       Impact factor: 60.716

6.  A trinuclear copper(II) complex of 2,4,6-tris(di-2-pyridylamine)-1,3,5-triazine shows prominent DNA cleavage activity.

Authors:  Jingwen Chen; Xiaoyong Wang; Ying Shao; Jianhui Zhu; Yangguang Zhu; Yizhi Li; Qiang Xu; Zijian Guo
Journal:  Inorg Chem       Date:  2007-03-14       Impact factor: 5.165

7.  Synergy between quantum dots and 1,10-phenanthroline-copper(II) complex towards cleaving DNA.

Authors:  Javier Hernández-Gil; Sacramento Ferrer Llusar; Carmen R Maldonado; Juan C Mareque-Rivas
Journal:  Chem Commun (Camb)       Date:  2011-01-17       Impact factor: 6.222

8.  X-ray structures of copper(II) and nickel(II) radical salen complexes: the preference of galactose oxidase for copper(II).

Authors:  Maylis Orio; Olivier Jarjayes; Hussein Kanso; Christian Philouze; Frank Neese; Fabrice Thomas
Journal:  Angew Chem Int Ed Engl       Date:  2010-07-05       Impact factor: 15.336

9.  Spin interaction in octahedral zinc complexes of mono- and diradical Schiff and mannich bases.

Authors:  M Orio; C Philouze; O Jarjayes; F Neese; F Thomas
Journal:  Inorg Chem       Date:  2010-01-18       Impact factor: 5.165

10.  A phenoxyl radical complex of copper(II).

Authors:  L Benisvy; A J Blake; D Collison; E S Davies; C D Garner; E J McInnes; J McMaster; G Whittaker; C Wilson
Journal:  Chem Commun (Camb)       Date:  2001-09-21       Impact factor: 6.222
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  2 in total

1.  Crystal structure of chlorido-(2-{1-[2-(4-chloro-phen-yl)hydrazin-1-yl-idene-κN]eth-yl}pyridine-κN)(η(5)-penta-methyl-cyclo-penta-dien-yl)rhodium(III) chloride.

Authors:  Neelakandan Devika; Nandhagopal Raja; Subbiah Ananthalakshmi; Bruno Therrien
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-02-07

2.  Crystal structure of chlorido-(2-{[2-(4-chloro-phen-yl)hydrazin-1-yl-idene-κN (1)](phen-yl)meth-yl}pyridine-κN)(η(5)-penta-methyl-cyclo-penta-dien-yl)iridium(III) tetra-phenyl-borate.

Authors:  Neelakandan Devika; Nandhagopal Raja; Subbiah Ananthalakshmi; Bruno Therrien
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-02-18
  2 in total

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