Literature DB >> 22352646

Noise characteristics of heterodyne/homodyne frequency-domain measurements.

Dongyel Kang1, Matthew A Kupinski.   

Abstract

We theoretically develop and experimentally validate the noise characteristics of heterodyne and/or homodyne measurements that are widely used in frequency-domain diffusive imaging. The mean and covariance of the modulated heterodyne output are derived by adapting the random amplification of a temporal point process. A multinomial selection rule is applied to the result of the temporal noise analysis to additionally model the spatial distribution of intensified photons measured by a charge-coupled device (CCD), which shows that the photon detection efficiency of CCD pixels plays an important role in the noise property of detected photons. The approach of using a multinomial probability law is validated from experimental results. Also, experimentally measured characteristics of means and variances of homodyne outputs are in agreement with the developed theory. The developed noise model can be applied to all photon amplification processes.

Entities:  

Mesh:

Year:  2012        PMID: 22352646      PMCID: PMC3603149          DOI: 10.1117/1.JBO.17.1.015002

Source DB:  PubMed          Journal:  J Biomed Opt        ISSN: 1083-3668            Impact factor:   3.170


  26 in total

1.  Analysis on performance and optimization of frequency-domain near-infrared instruments.

Authors:  Tao Tu; Yu Chen; Jun Zhang; Xavier Intes; Britton Chance
Journal:  J Biomed Opt       Date:  2002-10       Impact factor: 3.170

2.  Near-infrared fluorescence contrast-enhanced imaging with intensified charge-coupled device homodyne detection: measurement precision and accuracy.

Authors:  Alan B Thompson; Eva M Sevick-Muraca
Journal:  J Biomed Opt       Date:  2003-01       Impact factor: 3.170

3.  Effect of noise on modulation amplitude and phase in frequency-domain diffusive imaging.

Authors:  Dongyel Kang; Matthew A Kupinski
Journal:  J Biomed Opt       Date:  2012-01       Impact factor: 3.170

4.  Experimental demonstration of an analytic method for image reconstruction in optical diffusion tomography with large data sets.

Authors:  Zheng-Min Wang; George Y Panasyuk; Vadim A Markel; John C Schotland
Journal:  Opt Lett       Date:  2005-12-15       Impact factor: 3.776

5.  Hardware assessment using the multi-module, multi-resolution system (M3R): a signal-detection study.

Authors:  Jacob Y Hesterman; Matthew A Kupinski; Eric Clarkson; Harrison H Barrett
Journal:  Med Phys       Date:  2007-07       Impact factor: 4.071

6.  Theoretical investigation of the photon efficiency in frequency-domain fluorescence lifetime imaging microscopy.

Authors:  Alan Elder; Simon Schlachter; Clemens F Kaminski
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  2008-02       Impact factor: 2.129

7.  Optimization of the signal-to-noise ratio of frequency-domain instrumentation for near-infrared spectro-imaging of the human brain.

Authors:  Vlad Toronov; Enrico D'Amico; Dennis Hueber; Enrico Gratton; Beniamino Barbieri; Andrew Webb
Journal:  Opt Express       Date:  2003-10-20       Impact factor: 3.894

8.  Optimal source-modulation frequencies for transport-theory-based optical tomography of small-tissue volumes.

Authors:  Hyun Keol Kim; Uwe J Netz; Jürgen Beuthan; Andreas H Hielscher
Journal:  Opt Express       Date:  2008-10-27       Impact factor: 3.894

9.  Image analysis for denoising full-field frequency-domain fluorescence lifetime images.

Authors:  B Q Spring; R M Clegg
Journal:  J Microsc       Date:  2009-08       Impact factor: 1.758

10.  Human- and model-observer performance in ramp-spectrum noise: effects of regularization and object variability.

Authors:  C K Abbey; H H Barrett
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  2001-03       Impact factor: 2.129

View more
  3 in total

1.  Effect of noise on modulation amplitude and phase in frequency-domain diffusive imaging.

Authors:  Dongyel Kang; Matthew A Kupinski
Journal:  J Biomed Opt       Date:  2012-01       Impact factor: 3.170

2.  Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition.

Authors:  Jong Hwan Lee; Hyun Keol Kim; Chandhanarat Chandhanayingyong; Francis Young-In Lee; Andreas H Hielscher
Journal:  Biomed Opt Express       Date:  2014-06-18       Impact factor: 3.732

3.  Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry.

Authors:  H Y Ban; M Schweiger; V C Kavuri; J M Cochran; L Xie; D R Busch; J Katrašnik; S Pathak; S H Chung; K Lee; R Choe; B J Czerniecki; S R Arridge; A G Yodh
Journal:  Med Phys       Date:  2016-07       Impact factor: 4.071

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.