H Y Ban1, M Schweiger2, V C Kavuri1, J M Cochran1, L Xie3, D R Busch4, J Katrašnik5, S Pathak1, S H Chung1, K Lee6, R Choe7, B J Czerniecki8, S R Arridge2, A G Yodh1. 1. Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104. 2. Department of Computer Science, University College London, London WC1E 7JE, United Kingdom. 3. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104. 4. Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104. 5. Faculty of Electrical Engineering, University of Ljubljana, Ljubljana 1000, Slovenia. 6. Daegu Gyeongbuk Institute of Science and Technology, Daegu 711-813, South Korea. 7. Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642. 8. Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Abstract
PURPOSE: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. METHODS: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source-detector pairs (10(6)). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. RESULTS: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. CONCLUSIONS: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.
PURPOSE: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. METHODS: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source-detector pairs (10(6)). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. RESULTS: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancerpatient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. CONCLUSIONS: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.
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