Literature DB >> 22313030

Dynamics of DNA methylation in aging and Alzheimer's disease.

Hasan A Irier1, Peng Jin.   

Abstract

Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to be essential components of epigenetic regulation in the mammalian central nervous system. In this review, we provide an overview of the literature on DNA methylation in neurodegenerative diseases, with a special focus on methylation of 5-position of cytosine base (5mC) and hydroxymethylation of 5-position of cytosine base (5hmC) in the context of neurodegeneration associated with aging and Alzheimer's disease.

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Year:  2012        PMID： 22313030      PMCID： PMC3461976          DOI： 10.1089/dna.2011.1565

Source DB:  PubMed          Journal:  DNA Cell Biol        ISSN： 1044-5498            Impact factor:   3.311


  91 in total

1.  Global DNA demethylation during mouse erythropoiesis in vivo.

Authors:  Jeffrey R Shearstone; Ramona Pop; Christoph Bock; Patrick Boyle; Alexander Meissner; Merav Socolovsky
Journal:  Science       Date:  2011-11-11       Impact factor: 47.728

Review 2.  Epigenetic modifications and human disease.

Authors:  Anna Portela; Manel Esteller
Journal:  Nat Biotechnol       Date:  2010-10       Impact factor: 54.908

3.  Exercise enhances learning and hippocampal neurogenesis in aged mice.

Authors:  Henriette van Praag; Tiffany Shubert; Chunmei Zhao; Fred H Gage
Journal:  J Neurosci       Date:  2005-09-21       Impact factor: 6.167

4.  Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

Authors:  Yu-Fei He; Bin-Zhong Li; Zheng Li; Peng Liu; Yang Wang; Qingyu Tang; Jianping Ding; Yingying Jia; Zhangcheng Chen; Lin Li; Yan Sun; Xiuxue Li; Qing Dai; Chun-Xiao Song; Kangling Zhang; Chuan He; Guo-Liang Xu
Journal:  Science       Date:  2011-08-04       Impact factor: 47.728

5.  Global prevalence of dementia: a Delphi consensus study.

Authors:  Cleusa P Ferri; Martin Prince; Carol Brayne; Henry Brodaty; Laura Fratiglioni; Mary Ganguli; Kathleen Hall; Kazuo Hasegawa; Hugh Hendrie; Yueqin Huang; Anthony Jorm; Colin Mathers; Paulo R Menezes; Elizabeth Rimmer; Marcia Scazufca
Journal:  Lancet       Date:  2005-12-17       Impact factor: 79.321

Review 6.  Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives.

Authors:  Yves Rolland; Gabor Abellan van Kan; Bruno Vellas
Journal:  J Am Med Dir Assoc       Date:  2008-06-02       Impact factor: 4.669

7.  DNA methylation and cognitive functioning in healthy older adults.

Authors:  Olga J G Schiepers; Martin P J van Boxtel; Renate H M de Groot; Jelle Jolles; Frans J Kok; Petra Verhoef; Jane Durga
Journal:  Br J Nutr       Date:  2011-07-27       Impact factor: 3.718

8.  Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.

Authors:  Khursheed Iqbal; Seung-Gi Jin; Gerd P Pfeifer; Piroska E Szabó
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-14       Impact factor: 11.205

9.  Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease.

Authors:  Syed Waseem Bihaqi; Hui Huang; Jinfang Wu; Nasser H Zawia
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

10.  Synthesis of stable-isotope enriched 5-methylpyrimidines and their use as probes of base reactivity in DNA.

Authors:  Artur Burdzy; Katherine T Noyes; Victoria Valinluck; Lawrence C Sowers
Journal:  Nucleic Acids Res       Date:  2002-09-15       Impact factor: 16.971
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  38 in total

1.  Effect of valproic acid on mitochondrial epigenetics.

Authors:  Hu Chen; Svetlana Dzitoyeva; Hari Manev
Journal:  Eur J Pharmacol       Date:  2012-06-20       Impact factor: 4.432

Review 2.  Genomic integrity and the ageing brain.

Authors:  Hei-man Chow; Karl Herrup
Journal:  Nat Rev Neurosci       Date:  2015-10-14       Impact factor: 34.870

Review 3.  5-Hydroxymethylcytosine: A new player in brain disorders?

Authors:  Ying Cheng; Alison Bernstein; Dahua Chen; Peng Jin
Journal:  Exp Neurol       Date:  2014-05-17       Impact factor: 5.330

Review 4.  Epigenetics in Alzheimer's Disease: Perspective of DNA Methylation.

Authors:  Talal Jamil Qazi; Zhenzhen Quan; Asif Mir; Hong Qing
Journal:  Mol Neurobiol       Date:  2017-01-14       Impact factor: 5.590

5.  Salt-Induced Tissue-Specific Cytosine Methylation Downregulates Expression of HKT Genes in Contrasting Wheat (Triticum aestivum L.) Genotypes.

Authors:  Suresh Kumar; Ananda Sankara Beena; Monika Awana; Archana Singh
Journal:  DNA Cell Biol       Date:  2017-02-16       Impact factor: 3.311

Review 6.  Analyzing the cancer methylome through targeted bisulfite sequencing.

Authors:  Eun-Joon Lee; Junfeng Luo; James M Wilson; Huidong Shi
Journal:  Cancer Lett       Date:  2012-11-28       Impact factor: 8.679

7.  Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

Authors:  Christopher W Ng; Ferah Yildirim; Yoon Sing Yap; Simona Dalin; Bryan J Matthews; Patricio J Velez; Adam Labadorf; David E Housman; Ernest Fraenkel
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-22       Impact factor: 11.205

8.  5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity.

Authors:  Alison I Bernstein; Yunting Lin; R Craig Street; Li Lin; Qing Dai; Li Yu; Han Bao; Marla Gearing; James J Lah; Peter T Nelson; Chuan He; Allan I Levey; Jennifer G Mullé; Ranhui Duan; Peng Jin
Journal:  Hum Mol Genet       Date:  2016-04-09       Impact factor: 6.150

9.  Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.

Authors:  Hasan Irier; R Craig Street; Ronak Dave; Li Lin; Catherine Cai; Timothy Hayden Davis; Bing Yao; Ying Cheng; Peng Jin
Journal:  Genomics       Date:  2014-09-07       Impact factor: 5.736

Review 10.  Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies.

Authors:  Katie Lunnon; Jonathan Mill
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2013-09-13       Impact factor: 3.568
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