Literature DB >> 26462757

Genomic integrity and the ageing brain.

Hei-man Chow1,2, Karl Herrup1.   

Abstract

DNA damage is correlated with and may drive the ageing process. Neurons in the brain are postmitotic and are excluded from many forms of DNA repair; therefore, neurons are vulnerable to various neurodegenerative diseases. The challenges facing the field are to understand how and when neuronal DNA damage accumulates, how this loss of genomic integrity might serve as a 'time keeper' of nerve cell ageing and why this process manifests itself as different diseases in different individuals.

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Year:  2015        PMID： 26462757     DOI： 10.1038/nrn4020

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  198 in total

Review 1.  Changes of telomere length with aging.

Authors:  Kaiyo Takubo; Junko Aida; Naotaka Izumiyama-Shimomura; Naoshi Ishikawa; Motoji Sawabe; Rie Kurabayashi; Hiroaki Shiraishi; Tomio Arai; Ken-Ichi Nakamura
Journal:  Geriatr Gerontol Int       Date:  2010-07       Impact factor: 2.730

2.  Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia.

Authors:  Lawrence S Honig; Nicole Schupf; Joseph H Lee; Ming X Tang; Richard Mayeux
Journal:  Ann Neurol       Date:  2006-08       Impact factor: 10.422

3.  Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors:  Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

Review 4.  Molecular mechanisms of mammalian global genome nucleotide excision repair.

Authors:  Ludovic C J Gillet; Orlando D Schärer
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

Review 5.  Dyskeratosis congenita as a disorder of telomere maintenance.

Authors:  Nya D Nelson; Alison A Bertuch
Journal:  Mutat Res       Date:  2011-07-02       Impact factor: 2.433

6.  SIRT6 promotes DNA repair under stress by activating PARP1.

Authors:  Zhiyong Mao; Christopher Hine; Xiao Tian; Michael Van Meter; Matthew Au; Amita Vaidya; Andrei Seluanov; Vera Gorbunova
Journal:  Science       Date:  2011-06-17       Impact factor: 47.728

7.  Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Authors:  Arkady Celeste; Oscar Fernandez-Capetillo; Michael J Kruhlak; Duane R Pilch; David W Staudt; Alicia Lee; Robert F Bonner; William M Bonner; André Nussenzweig
Journal:  Nat Cell Biol       Date:  2003-07       Impact factor: 28.824

8.  Mammalian microRNAs predominantly act to decrease target mRNA levels.

Authors:  Huili Guo; Nicholas T Ingolia; Jonathan S Weissman; David P Bartel
Journal:  Nature       Date:  2010-08-12       Impact factor: 49.962

9.  Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Authors:  Rui-Hong Wang; Kundan Sengupta; Cuiling Li; Hyun-Seok Kim; Liu Cao; Cuiying Xiao; Sangsoo Kim; Xiaoling Xu; Yin Zheng; Beverly Chilton; Rong Jia; Zhi-Ming Zheng; Ettore Appella; Xin Wei Wang; Thomas Ried; Chu-Xia Deng
Journal:  Cancer Cell       Date:  2008-10-07       Impact factor: 31.743

10.  RETRACTED: Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.

Authors:  Maria Fousteri; Wim Vermeulen; Albert A van Zeeland; Leon H F Mullenders
Journal:  Mol Cell       Date:  2006-08       Impact factor: 17.970
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  77 in total

Review 1.  Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

Authors:  Jesse S Kerr; Bryan A Adriaanse; Nigel H Greig; Mark P Mattson; M Zameel Cader; Vilhelm A Bohr; Evandro F Fang
Journal:  Trends Neurosci       Date:  2017-02-09       Impact factor: 13.837

2.  Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression.

Authors:  François-Xavier Blaudin de Thé; Hocine Rekaik; Eugenie Peze-Heidsieck; Olivia Massiani-Beaudoin; Rajiv L Joshi; Julia Fuchs; Alain Prochiantz
Journal:  EMBO J       Date:  2018-06-25       Impact factor: 11.598

Review 3.  DNA damage in the oligodendrocyte lineage and its role in brain aging.

Authors:  Kai-Hei Tse; Karl Herrup
Journal:  Mech Ageing Dev       Date:  2016-05-26       Impact factor: 5.432

4.  Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis.

Authors:  Yinyin Li; Yi Shen; Philipp Hohensinner; Jihang Ju; Zhenke Wen; Stuart B Goodman; Hui Zhang; Jörg J Goronzy; Cornelia M Weyand
Journal:  Immunity       Date:  2016-10-11       Impact factor: 31.745

5.  DNA damage responses in central nervous system and age-associated neurodegeneration.

Authors:  Muralidhar L Hegde; Vilhelm A Bohr; Sankar Mitra
Journal:  Mech Ageing Dev       Date:  2017-01       Impact factor: 5.432

Review 6.  Coordination of DNA single strand break repair.

Authors:  Rachel Abbotts; David M Wilson
Journal:  Free Radic Biol Med       Date:  2016-11-24       Impact factor: 7.376

Review 7.  Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.

Authors:  Michael J Berridge
Journal:  J Physiol       Date:  2017-10-31       Impact factor: 5.182

8.  Loopholes in the DNA contract kill neurons.

Authors:  Karl Herrup; Kai-Hei Tse; Hei-Man Chow
Journal:  Nat Neurosci       Date:  2017-08-29       Impact factor: 24.884

9.  DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia.

Authors:  Kai-Hei Tse; Aifang Cheng; Fulin Ma; Karl Herrup
Journal:  Alzheimers Dement       Date:  2018-01-09       Impact factor: 21.566

10.  NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

Authors:  Yujun Hou; Sofie Lautrup; Stephanie Cordonnier; Yue Wang; Deborah L Croteau; Eduardo Zavala; Yongqing Zhang; Kanako Moritoh; Jennifer F O'Connell; Beverly A Baptiste; Tinna V Stevnsner; Mark P Mattson; Vilhelm A Bohr
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-05       Impact factor: 11.205
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