Literature DB >> 24845851

5-Hydroxymethylcytosine: A new player in brain disorders?

Ying Cheng1, Alison Bernstein2, Dahua Chen3, Peng Jin4.   

Abstract

5-Hydroxymethylcytosine (5 hmC), a novel modified cytosine, is oxidized from 5-methylcytosine (5 mC) by the ten-eleven translocation (Tet) protein family. The specific distribution of 5 hmC in mammalian brain and its roles in gene regulation suggest that 5 hmC is important in brain development. 5 hmC may also contribute to the mechanisms underlying neurological diseases. Here, we summarize the current knowledge of 5 hmC, with an emphasis on its roles in neurodevelopmental and neurodegenerative disorders.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  5-Hydroxymethylcytosine (5hmC); 5-Methylcytosine (5mC); Neurodegenerative disease; Neurodevelopmental disorder; Ten-eleven translocation (Tet) protein

Mesh：

Substances：

Year:  2014        PMID： 24845851      PMCID： PMC4234697          DOI： 10.1016/j.expneurol.2014.05.008

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


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